Malignant blood diseases associated with thrombosis

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Leukemia is a malignancy involving blood clots that affects the blood cells, lymph nodes, and bone marrow. There are many ways to classify diseases, but currently they are divided into 2 types according to their cell origin: myeloid and lymphoid.

1. What is Thrombosis?

Thrombosis is a blood clot in the blood vessels. Thrombosis can occur in all types of blood vessels, most of which appear in the veins, especially the veins located deep inside the body, often in the legs, causing deep vein thrombosis.

2. Classification of blood malignancies

Hematologic malignancies are cancers that affect the blood cells, lymph nodes, and bone marrow. There are many ways to classify hematologic malignancies, but they are generally divided into two main groups:

2.1 Leukemia-related disease

Acute lymphocytic leukemia Acute myeloid leukemia Acute myeloid leukemia Acute mononucleosis Acute other cell leukemia

2.2 Lymphoma-related diseases

2.2.1 Hodgkin's Lymphoma

Usually originates from the B-lymphocyte line. There are 4 main types: nodular fibrosis, mixed cell, lymphocyte-rich, and low-lymphocyte.

2.2.2 Non-Hodgkin's Lymphoma

Includes many different types depending on the cell origin divided into two main groups: Non-Hodgkin lymphoma T cell line and Non-Hodgkin lymphoma B cell line.
In addition, patients with cancer will have an increased risk of blood clot formation due to many reasons. Aortic thrombosis is a rare but potentially devastating complication in cancer patients receiving cisplatin-based chemotherapy. Patients need early diagnosis and definitive treatment to reduce morbidity and mortality.

3. Skin manifestations of malignant blood diseases

3.1 Due to infectious etiology

Common manifestations are staphylococcus aureus infection, green pus-filled bacilli causing skin abscesses or ulcers, mycobacterium infection, cellulitis or severe and diffuse viral infections: HPV virus, shingles, Herpes simplex virus.
In more severe cases, the patient may have cutaneous and visceral candidiasis or sepsis.

3.2 Due to immune disorders

Patients will present with sudden onset of fever, increased neutrophils in the blood, and the appearance of many red modules or patches under the skin, causing pain, possibly ulcers. Usually doctors will treat patients with systemic corticosteroids.
Immune disorders also cause necrotizing pustulitis, manifested by very painful tumors, lumps, and nodules, which quickly burst to form sore margins, red and purple, with repeated episodes, common in areas The brain has microtrauma and also responds well to systemic corticosteroids. The disease is also common in the group of acute myeloid leukemia and multiple myeloma.

3.3 Skin manifestations of T-cell lymphoma

Malignant T cells in the body will initially migrate to the skin causing various lesions to appear. Lesions change as the disease progresses, often starting with an itchy rash and eventually forming plaques and tumors before spreading to other parts of the body.
There are different groups of diseases, which can be classified into:
Mycosis Fungoid Other forms of MF(Folliculin Tropic mycosis fungoides, Pagetoid reticulosis, Granulomatous slack skin Sezary syndrome Adult cutaneous T-lymphoma) CD 30 (+) on the skin include: large cell lymphoma, and papulocutaneous lymphoma Subcutaneous panniculitis-like T-cell lymphoma Extra-nodal NK cells Malignant blood clots associated with thrombosis will usually present with a small red rash that is raised on the skin and gradually progresses to itching, pain, and sores after a period of time. Currently, Vinmec International General Hospital not only has a team of experienced and qualified medical professionals, but also a hospital that is always at the forefront of technology improvement, leading modern and advanced testing techniques in the world, the hospital is one of the few medical examination and treatment facilities that fully meets all medical conditions. diagnostic tests, disease detection and monitoring, is a trusted destination for examination and treatment.
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