Effects and notes when using Cyclogest 400mg

This is an automatically translated article.

The article was advised by Pharmacist Duong Thanh Hai - Clinical Pharmacist - Faculty of Pharmacy - Vinmec Times City International Hospital

Cyclogest suppository 400mg is used to treat premenstrual syndrome as well as many other gynecological conditions. So, in order for the drug to be most effective, what should the patient pay attention to?

1. Cyclogest 400mg what effect?

Cyclogest suppository 400mg has the active ingredient progesterone - a natural female hormone. It is used to treat premenstrual syndrome (mood swings, breast tenderness, appetite, fatigue, irritability, depression), to treat postpartum depression, and to use in assisted reproductive technology. infertility treatment - infertility, threatened miscarriage cases. Progesterone is a hormone needed to maintain the normal function of the reproductive organs and its levels naturally change throughout the menstrual cycle.
After ovulation, if not fertilized, the level of progesterone in the blood drops before menstruation begins. Progesterone for 12-14 days before menstruation helps relieve uncomfortable symptoms of menstruation. However, this mechanism is still not fully understood, as PMS has not been scientifically proven to be caused by a lack of progesterone in the blood.
Progesterone can be used to treat postpartum depression. The placenta produces progesterone throughout pregnancy, and a drop in progesterone levels after delivery can be one of the causes of postpartum depression.
Progesterone is also used to support early pregnancy in women undergoing in vitro fertilization (IVF). In this case, Cyclogest 400mg suppository was administered on the day of egg harvest. Progesterone acts on the lining of the uterus and causes it to thicken in preparation for the implantation of a fertilized egg. The drug is continued when pregnancy is confirmed until the placenta is fully developed to take over the production of progesterone.

2. How to use Cyclogest?

Cyclogest 400mg suppository is used by inserting into the vagina or anus. In both cases, the pill will melt and the progesterone from the pill is absorbed into the general circulation by the blood vessels in these areas. If Cyclogest is used for assisted reproduction, it is given via the intravenous route. vagina.

To treat premenstrual syndrome or postpartum depression, you can choose 1 of 2 ways to put the medicine (in the vagina or anus) depending on each person's preferences. However, if you are using latex condoms or birth control caps, you should use the anal route to avoid the drug affecting these protective barriers. Similarly, rectal suppositories should be used if vaginal infections, recurrent UTIs, or recent childbirth have been reported. Conversely, if you have inflammatory bowel disease (colitis) or any other problem in controlling bowel movements, a vaginal route should be used.
3. When should you not use Cyclogest? Which of the following people should not use Cyclogest?
Women with abnormal vaginal bleeding with no known cause. Women with a rare inherited blood disorder called porphyria. Have severe liver disease. Have a known or suspected progesterone-sensitive tumor, such as breast cancer or cancer of the genital tract. Women with phlebitis caused by blood clots, such as in the legs (deep vein thrombosis) or in the lungs (pulmonary embolism), women who have ever had a heart attack or stroke. Cases requiring caution when using Cyclogest are women at high risk of blood clots in the blood vessels, hypertension, cardiovascular disease, liver/kidney failure, epilepsy, asthma, migraines. Progesterone is excreted in breast milk, so women should not use the drug while breastfeeding.
4. What side effects does Cyclogest have? The following are some of the side effects known to be associated with Cyclogest (this does not mean that all people using this medicine will experience them):
Common: Drowsiness, stomach upset or sugar upset digestion, breast tenderness, hot flushes, constipation, and fatigue (when used in assisted conception). Possible: Disturbance of the menstrual cycle, increased mucus from the vagina or anus, vaginal pain, site pain, diarrhea and flatulence with the anorectal route.

5. What drugs can Cyclogest interact with? Some of the following drugs that can affect the effect of progesterone are: carbamazepine, fosphenytoin, oxcarbazepine, phenobarbital, phenytoin, primidone, rifampicin. Tell your doctor if you are taking these medications.
Cyclogest suppository 400mg is used to treat premenstrual syndrome as well as many other gynecological conditions. To ensure effective treatment, patients need to take prescription drugs. In case of abnormality, the patient needs to go to medical centers for examination and treatment.

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