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Voltaren 75mg medicine contains the active ingredient diclofenac sodium is indicated in the treatment of inflammation and pain after surgery or injury, osteoarthritis pain, adnexitis, menstrual pain... Let's find out the dosage of Voltaren 75mg Read the article below to use the drug safely.
1. Uses of Voltaren 75mg
1.1. What is Voltaren 75mg used for? Voltaren 75mg is indicated in the following conditions:
Inflammatory, painful and degenerative forms of joint diseases including: Ankylosing spondylitis, rheumatoid arthritis, spinal pain syndrome, arthritis spondylitis and osteoarthritis, extra-articular rheumatism; Inflammation, pain and swelling after surgery or after trauma such as orthopedic surgery, dental surgery; Inflammation and pain in gynecology such as adnexitis, primary dysmenorrhea. 1.2. Pharmacodynamics Active ingredient Diclofenac has been shown to significantly reduce the symptoms and signs of pain including pain at rest, morning stiffness, pain with movement, joint swelling, while helping to improve the function of the joints. joint. In inflammatory conditions after surgery and trauma, Voltaren provides symptomatic relief of spontaneous pain and pain with movement, reducing wound edema and reducing inflammation. Voltaren 75mg is available in many different forms such as Voltaren 75mg topical, regular tablets and extended release tablets. In which the extended-release form is very suitable and convenient for patients taking a dose of 75mg/day. Single daily dosing simplifies long-term treatment and avoids dosage confusion. Voltaren 75mg content also allows the maximum dose of 150mg divided into 2 times a day.
1.3. Pharmacokinetics Absorption: Voltaren 75 mg is administered as an extended release formulation, so peak plasma concentrations are lower than those observed when administered as gastric insoluble tablets at the recommended dose. equivalent. The pharmacokinetics of the drug did not change significantly with repeated dosing and no accumulation occurred between the recommended doses. Food does not affect the absorption and systemic effects of Voltaren extended-release tablets. Distribution: Approximately 99.7% of the dose is bound to plasma proteins (mainly albumin accounting for 99.4%). The apparent volume of distribution is about 0.12 – 0.17 L/kg. Active ingredient diclofenac enters the synovial fluid, reaching maximum concentration after 2-4 hours, reaching maximum plasma concentration. Metabolism: Occurs partly by glucuronide of the intact molecule and mainly by hydrolysis, single or multiple methoxylation to yield a phenolic metabolite. Most of these metabolites are converted to conjugated glucuronides. Of these, two phenolic metabolites are biologically active, but biologically less active than diclofenac. Elimination: Approximately 60% of the active substance diclofenac is excreted in the urine as the intact conjugated glucuronide and as metabolites. All of these are then converted to conjugated glucuronides. Less than 1% of the active substance is excreted unchanged, the remainder is excreted in the bile as faeces.
2. Dosage
Dosage of Voltaren 75mg depends on the patient's condition and absorption level. The dose should be prescribed by the treating doctor, all recommended doses are approximate. Patients should absolutely not self-medicate without a doctor's prescription. The recommended dosage of Voltaren 75mg is as follows:
General population:
The recommended starting dose is 100 - 150mg/day; In case of mild symptoms and long-term treatment is required, the recommended dose is 75-100mg/day; In case the patient's symptoms are worse at night or in the morning, Voltaren 75mg or 100mg extended-release tablets should be taken in the evening. Special patient groups:
Children: Voltaren 75mg and 100mg extended release are not indicated in children and adolescents; Elderly: There is no need to adjust the starting dose in elderly patients; Patients with cardiovascular disease or significant cardiovascular risk factors: Treatment with Voltaren is not recommended in these subjects. In case of necessity, use only a dose of less than 100mg/day; Patients with renal impairment: Contraindicated in patients with severe renal impairment. Voltaren should be used with caution in patients with mild to moderate renal impairment; Patients with hepatic impairment: Contraindicated in patients with severe hepatic impairment. Voltaren should be used with caution in patients with mild to moderate hepatic impairment.
3. Voltaren 75mg . side effects
Voltaren 75mg medicine can cause some side effects as follows:
Nervous system disorders such as dizziness, headache; Ear and Vestibular Disorders: Dizziness; Gastrointestinal disorders: Diarrhea, nausea, dyspepsia, vomiting, flatulence, abdominal pain, loss of appetite; Hepatobiliary disorders: Increased blood transaminase levels; Skin and subcutaneous tissue disorders: Rash. Heart disorders such as heart failure, myocardial infarction, chest pain, palpitations. In case of experiencing side effects, the patient should stop using the drug and immediately notify the doctor or go to the nearest medical facility for timely treatment.
4. Note when using
4.1. Contraindications Contraindicated to use Voltaren 75mg in the following cases:
The patient is allergic to any of Voltaren's ingredients; The patient is suffering from active inflammation, peptic ulcer, bleeding or perforation of the gastrointestinal tract; Pregnant women in the last 3 months of pregnancy; Patients with severe liver failure; Patients with severe kidney failure, heart failure; Similar to other non-steroidal anti-inflammatory drugs (NSAIDs), Voltaren 75mg is contraindicated in patients with bronchial asthma, urticaria or acute rhinitis when using NSAIDs or acetylsalicylic acid. 4.2. Use with caution Gastrointestinal effects: Voltaren in particular and other NSAIDs in general have been reported to have a risk of gastrointestinal ulceration, bleeding or perforation. The risk of this condition increases in the elderly. In case of bleeding, peptic ulcer in patients treated with Voltaren, the drug should be discontinued, the starting dose and maintenance dose should be used at the lowest effective dose. In some cases, combination therapy with protective agents (misoprostol or proton pump inhibitors) should be considered in these patients. Cardiovascular Effects: Long-term (especially high-dose) treatment with Voltaren in particular and with NSAIDs in general is associated with an increased risk of serious cardiovascular thrombotic events (including sudden stroke and myocardial infarction). In general, the use of Voltaren is not recommended in patients with cardiovascular disease. Effects on hematology: Patients should be monitored periodically for blood counts during long-term treatment with NSAIDs. Respiratory effects: Reactions to NSAIDs such as urticaria, Quinck's edema, and exacerbations of asthma are common in patients with previous asthma attacks. Therefore, special attention should be paid to this patient. Effects on the hepatobiliary system: Voltaren used in patients with impaired liver function should be closely monitored because the drug increases the risk of liver failure. Renal Effects: Treatment with diclofenac and other NSAIDs can cause edema and fluid retention, so special care should be taken when treating patients with compromised cardiac or renal function, patients with a history of hypertension pressure, patients are being treated concurrently with diuretics or drugs that affect kidney function... Effects on skin: Serious reactions such as exfoliative dermatitis, toxic epidermal necrolysis, Stevens-Johnson syndrome has been reported in rare cases in patients treated with NSAIDs. Elderly: Caution should be exercised when using Voltaren in the elderly. In particular, it is recommended that the lowest effective dose be used in frail elderly or underweight patients. Medicines can mask the signs of infection. Pregnancy: There are no adequate data on the safety of diclofenac in pregnant women. Therefore, the drug should not be used during the first and second trimesters of pregnancy (unless the benefits outweigh the risks). Contraindicated when using the drug in pregnant women in the last 3 months of pregnancy. Lactation: Diclofenac is likely to be excreted in human milk in small amounts. Therefore, the drug should not be used in lactating women to avoid unwanted effects.
5. Drug interactions
Voltaren 75mg drug may have some interactions when combined with some drugs / drug groups such as:
Non-steroidal anti-inflammatory drugs (NSAIDs): Using diclofenac with diclofenac may increase the risk of gastrointestinal bleeding . Therefore, do not use combinations of NSAIDs; Diuretics and treatment of hypertension: Concomitant use with diclofenac may reduce the antihypertensive effect of the drug; Cardiac Glycosides: Exacerbation of heart failure, impaired renal function and increased plasma glycoside concentrations; Antiplatelet agents, anticoagulants : Use with caution in combination with diclofenac because of the increased risk of bleeding; Quinolone antibiotics: May lead to risk of convulsions; Lithium: Voltaren increases plasma concentrations of lithium. Therefore, it is necessary to monitor the serum lithium concentration; Methotrexate: Voltaren inhibits the renal clearance of methotrexate, thereby increasing the concentration of methotrexate, increasing the risk of toxicity; Cyclosporin: Increased nephrotoxicity of cyclosporin; Digoxin: Diclofenanc increases the concentration of digoxin in the blood plasma; Phenytoin: Plasma concentrations of phenytoin should be monitored when used in combination with diclofenac.
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