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Flotral is used to treat symptoms caused by benign prostatic hyperplasia. The drug is mainly used to control symptoms, not to shrink the gland, because the drug has the effect of relaxing smooth muscle, limiting the spasm of smooth muscle in the ureter and bladder, causing obstruction to the urinary tract.1. What is Flotral 10mg?
Flotral 10mg has the main ingredient is Alfuzosin hydrochloride 10mg and other excipients, made in the form of tablets. Alfuzosin hydrochloride is a selective antagonist of postsynaptic α1-adrenoreceptors, which are present in the prostate gland, the fundus of the bladder, the bladder neck, the membrane surrounding the prostate, and the urethra. By inhibiting these α1-adrenoreceptors, it relaxes smooth muscle in the bladder neck and prostate gland, thereby improving urine flow obstruction and reducing symptoms of benign prostatic hyperplasia. paralysis.
The reason in the pathology of benign prostatic hyperplasia, the patient often has symptoms of difficulty urinating, urinary retention, straining to urinate... the cause may be due to pressing pressure on the urine outlet, but usually due to spasm of smooth muscle of the bladder and urethra. Since then, the drug has an effect, so the new smooth muscle relaxation helps to reduce the uncomfortable symptoms of the patient.
In addition, on the cardiovascular system alfuzosin also has anti-hypertensive effects.
2. What disease does Flotral 10mg treat?
Flotral 10mg is indicated in the following cases: Treatment of signs and symptoms of benign prostatic hyperplasia (BPH) such as dysuria, urinary retention...
The drug should not be used in these cases. In the following cases:
Should not be used in patients with moderate to severe hepatic impairment because the drug is metabolized mainly by the liver, so in patients with liver disease, blood levels of alfuzosin are increased in these patients. Concomitant use of drugs such as ketoconazole, itraconazole, and ritonavir should not be given to patients with known hypersensitivity to alfuzosin hydrochloride or any of the excipients. A history of orthostatic hypotension should be used with caution. Do not give this medicine to children. Caution should be exercised when used in certain subjects:
Coronary heart failure : If new or worsening symptoms of angina occur, alfuzosin should be discontinued. Mild liver failure has not been specifically studied in these cases. Renal impairment: An evaluation study on patients with mild, moderate and severe renal impairment. The safety profile in patients with moderate to mild renal impairment was similar to that in patients with normal renal function in this study. For patients with severe renal impairment with creatinine clearance less than 30 ml/min, safety has not been adequately evaluated. Therefore, caution should be exercised when administering this drug to patients with severe renal impairment. Patients with Congenital or Acquired Electrocardiographic prolongation of the QT interval: Caution should be exercised when deciding whether to prescribe this drug to patients with a history of QT prolongation or to patients taking other drugs prolongation of the QT interval. Because there is a risk of causing changes in the conduction of the myocardium.
3. Dosage and how to use Flotral 10mg
Dosage:
For adults: The usual dose is 1 10mg tablet per day. Usually start at a small dose and gradually increase to a dose that is responsive and well tolerated. Elderly: There is no difference in dose compared with young people.
4. Notes when using Flotral 10mg
It is necessary to inform the doctor about medical history, current medications and allergies. To minimize unwanted effects. When taking the drug can cause some unwanted effects such as headache, dizziness, fatigue, digestive disorders, upper respiratory infections...if it affects your life, you should notify your doctor. for a suitable solution. Note that prostate cancer and benign prostatic hyperplasia share many of the same symptoms. Therefore, it is important to accurately diagnose the disease by examination before starting treatment with alfuzosin, to exclude the risk of prostate cancer. Drug Interactions: An interaction between alfuzosin and other alpha-blockers has not been determined. However, interactions are possible, so alfuzosin should not be used with other alpha-blockers. Orthostatic hypotension may occur within hours of taking alfuzosin hydrochloride. As with most alpha-blockers, this drug has the potential to cause a patient to experience hypotension leading to syncope. Patients should be informed before taking the drug about this risk and how to avoid situations where syncope may occur. It is not a determinant of drug discontinuation, but extreme caution should be exercised when alfuzosin hydrochloride is administered to patients with evidence of hypotension or in combination with antihypertensive agents. Because patients may experience postural hypotension during the initial period of taking the drug, care should be taken when operating machinery or vehicles. Flotral 10mg is used under the prescription of the treating doctor, so do not self-medicate when you see similar symptoms. When there is an abnormality in the process of taking the drug, it is advisable to notify the doctor so that the drug can be adjusted accordingly.
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