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Piotaz is a prescription drug group of hormones, hormones, the main ingredient is Pioglitazone hydrochloride, with 2 strengths of 15mg and 30mg. Piotaz is used to control blood sugar in people with type 2 diabetes. To better understand the use of the drug in diabetes, please read the following information in the article Piotaz drug use.1. What is Piotaz?
Piotaz 15 and piotaz 30 are drugs that contain the main active ingredient Pioglitazone (the dosage form Pioglitazone hydrochloride) and excipients, in the form of tablets, which are oral hypoglycemic drugs. The use of Piotaz is due to the pharmacological effects of Pioglitazone.Pioglitazone belongs to a class of thiazolidinedione derivatives, a different class of chemicals and has a different pharmacological effect than metformin, sulfonylureas or alpha glucosidase inhibitors. The drug works mainly by reducing insulin resistance, thereby lowering blood sugar. After 30 minutes of dosing in the fasted state, pioglitazone can be measured in the blood, reaching peak concentrations within 2 hours. Food delays peak blood levels of the drug by 3 to 4 hours without changing the extent of absorption. Pioglitazone is strongly bound to blood proteins (about 99%), mainly to albumin. The drug is extensively metabolised by oxidation and hydrolysis, the metabolite is partially converted to the conjugated form with sulfate and glucuronide. The mean blood half-life of pioglitazone ranges from 3 hours to 7 hours. The post-metabolized drug is eliminated by the kidneys primarily as metabolites and conjugates of the metabolites.
2. Indications and contraindications of Piotaz
2.1. Point
Piotaz is indicated as an adjunct to exercise and diet to improve glycemic control in patients with type 2 diabetes. Piotaz is indicated for use alone or in combination with other classes of antidiabetic drugs.
2.2. Contraindications
Do not use the drug when the patient is allergic to Pioglitazone, the ingredients in the drug. People with type 1 diabetes or people with ketoacidosis due to diabetic complications should not take Piotaz.
3. Dosage and how to use Piotaz
How to use: Piotaz is used orally, patients can take tablets with meals or between meals.
Dosage:
Starting dose: Take a single dose of 15mg - 30mg per day. The dose can be increased to 45mg once a day. Do not adjust the dose of Piotaz in patients with renal insufficiency. Do not use pioglitazone in children under 18 years of age. Patients should adhere to the dosage of Piotaz as directed by the doctor, in case of need to combine drugs, the dose of Piotaz can be adjusted and changed while taking the drug. Patients refer to the following drug combination dose:
Combined with Sulphonylurea: Use 15mg or 30mg oral dose once a day only. Combination with Metformin: 15mg or 30mg once a day. Combination with Insulin: Use oral dose from 15mg to 30mg once a day.
4. Undesirable effects of Piotaz
During the use of Piotaz, patients may experience the following undesirable effects: Headache, muscle pain, upper respiratory tract infection, edema, anemia, increased liver enzymes. If the patient has any of the symptoms listed above, or other unpleasant or unusual side effects while using Piotaz, please inform your doctor.
5. Notes during the use of Piotaz
It is necessary to inform your treating doctor what drugs and supplements you are taking because Piotaz may interact with them: Like drugs that reduce the effectiveness of oral contraceptives, Ketoconazole significantly inhibits the effectiveness of oral contraceptives. including the metabolism of pioglitazone in the drug,... Piotaz can be used as monotherapy. In the event that diet, exercise, and medication alone do not meet the goal, the doctor will prescribe a combination of drugs, noting the risk of hypoglycemia when using the combination of drugs. If the patient forgets to take a pill one day, the patient should not take a double dose of Piotaz the next day. There are no studies on the combination of the drug with any other thiazolidinedione. Treatment should not be initiated if the patient has clinical evidence of active liver disease or elevated blood transaminases (ALT values greater than 2.5 times the upper limit of normal) at the time of initiation of therapy. medicine. Patients should periodically monitor liver enzymes before and during taking Piotaz by testing.
Use hypoglycemic agents with caution in patients with edema. Piotaz should not be used in pregnant women, people under 18 years of age, and nursing mothers. Drivers and operators of machinery should be cautious when taking Piotaz. Above is Piotaz drug information. The drug is in oral tablet form, effective in treating people over 18 years of age in type 2 diabetes. The drug is prescribed, patients should not buy and use Piotaz on their own, using the wrong dose because it can cause harmful effects. complications of hypoglycemia. If you still have questions about Piotaz, consult your endocrinologist or other specialist.
