Uses of Glisan 30mg

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1. Uses of the drug Glisan 30mg

1.1. Indications Glisan 30mg drug contains the active ingredient gliclazide - belongs to the group of sulfonylurea hypoglycemic drugs, which stimulates insulin secretion by the islets of the pancreas, thereby indirectly helping to reduce blood glucose levels. The drug is indicated in the treatment regimen of type 2 diabetes in patients whose blood sugar cannot be controlled by diet.
1.2. Pharmacodynamics Active ingredient Gliclazide belongs to the group of sulfonylurea hypoglycemic agents, different from other related drugs in that Gliclazide has an additional azabicyclo-octane ring. The hypoglycemic effect of glicazid is through the mechanism of increasing insulin secretion mainly in phase 1 and to a lesser extent in phase 2. In patients with non-insulin dependent diabetes, both phases are reduced.
1.3. Pharmacokinetics After oral administration Gliclazide is readily absorbed from the gastrointestinal tract. The drug is strongly bound to plasma proteins. The half-life of Gliclazide ranges from 10 to 12 hours. The drug is extensively metabolised in the liver to a significant hypoglycemic inactive metabolite. The drug is unchanged and the metabolites are excreted in the urine.

2. Dosage of the drug Glisan 30mg

The use of Glisan 30mg in the treatment of diabetes depends on the dose of the drug. Accordingly, the dose of Glisan 30mg depends on the age and condition of the patient. Specifically as follows:
The recommended initial dose is 30 mg/day. Take the medicine every morning. After that, if blood sugar is stable, continue to maintain the original dose. In case blood sugar has not returned to the equilibrium state, it is necessary to increase the dose to 2-4 tablets / day in turn until a stable blood sugar level is maintained. Note that the maximum dose of Glisan is 120 mg/day (equivalent to 4 tablets/day); In case the patient is 65 years old or older or has moderate or low renal function impairment, the dose can be maintained as a normal person, but it is necessary to have close supervision of the treating doctor; In case of changing from 1 other blood glucose lowering drug to treatment with Glisan 30mg MR, it is necessary to note the half-life and the dose of the drug used before to avoid the occurrence of simultaneous effects of both drugs; Only perform treatment with Glisan 30mg when ensuring a regular diet, the amount of carbohydrates needs to be supplemented in each meal; It is possible to perform a combination treatment regimen of Glisan 30mg MR with insulin or alpha glucosidase inhibitors, biguanide drugs; Drug dosage must be used correctly. Patients should absolutely not increase or decrease the dose on their own without consulting the doctor. In addition, the patient should update the medical situation to the doctor to receive advice as well as change the treatment regimen when necessary; In case the patient misses a dose with a time not too far from the usual dose (about 3-4 hours), it should be taken as soon as he remembers. In case the missed dose is quite far from the usual dose (> 24 hours), the patient should take the drug as usual and absolutely do not make up for the missed dose by accumulating the new dose.

3. Contraindications of Glisan 30mg

Contraindicated to use Glisan 30mg drug in the following cases:
People who are sensitive to any component of the drug Glisan 30mg; Patients who are allergic to sulfonylureas and sulfonamides; Patients with impaired liver and kidney function; People with type 1 diabetes, juvenile diabetes and unstable diabetes; Patients with ketoacidosis, patients with diabetic coma; Pregnant women; People with diabetes after an injury, undergoing surgery or having an infection.

4. Note when using Glisan 30mg

4.1. Undesirable effects Some side effects may be encountered when using the drug Glisan 30mg as follows:
Digestive disorders such as loss of appetite, nausea, vomiting, diarrhea, belching, metallic taste in the mouth; Increased appetite, weight gain; Sensitivity to light, skin rash, itching, flushed face; Mild hypoglycemia may occur; Some rare side effects such as hepatitis, change in liver enzyme values, cholestatic jaundice, aplastic anemia, hemolytic anemia, thrombocytopenia, erythema multiforme or Stevent-Johnson syndrome, rash skin redness, exfoliative inflammation... 4.2. Notes on use Some notes when using Glisan 30mg drug are as follows:
Do not use Glisan in particular and drugs of the Sulfonylure group in general in the treatment of type 1 diabetes. The treatment of type 2 diabetes should be contraindicated in patients who have entered the stage of severe infection and ketoacidosis, have had trauma or other severe conditions for which sulfonylurea drugs have not controlled the increase in blood pressure. blood sugar; Where a sulfonylurea drug is needed in patients at increased risk of hypoglycemia, a short-acting drug such as gliclazide is more appropriate. Because the drug is inactivated mainly in the liver, it is suitable for patients with renal failure. However, it is still necessary to monitor blood glucose levels carefully; Patients should be warned of the dangers of hypoglycaemia while driving or operating machinery and that appropriate action should be taken in this situation (eg, stopping driving as soon as possible and taking additional precautions). earliest blood sugar). Patients with loss of consciousness due to frequent hypoglycemia should not drive; Lactation: Some drugs in the sulfonylurea group are distributed into breast milk, including gliclazide. Therefore, the use of this drug is contraindicated during lactation.

5. Glisan 30mg . drug interactions

Caution should be taken when using gliclazide with drugs that change the diabetic status or increase the effect of the drug.
The hypoglycemic effect of the drug is increased when used with drugs including salicylates, phenylbutazone, MAOIs, coumarin derivatives, tetracyclines, clofibrat, chloramphenicol, miconazole, disopyramid and cimetidine.
Gliclazide may be reduced when used with corticosteroids, thiazide diuretics, oral contraceptives, thyroid hormone...
Glisan 30mg medicine contains the active ingredient gliclazide - belongs to the group of sulfonylurea hypoglycemic drugs. It is indicated in the treatment of non-insulin dependent diabetes mellitus. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take medicine according to prescription or as directed by a doctor or pharmacist.
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