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Cleviprex contains the active ingredient Clevidipine, which relaxes vascular smooth muscle. The drug is indicated in the treatment of hypertension. So what is the dose and precautions when using Cleviprex?1. The effect of the drug Cleviprex
Cleviprex has the active ingredient Clevidipine, which belongs to the group of calcium channel blockers. The drug has the effect of relaxing the smooth muscle of the blood vessels. Cleviprex is used to treat high blood pressure in people who cannot take medication by mouth.2. Dosage and usage of Cleviprex
Dosage:In general, when used for hypertensive emergency, it is recommended to reduce mean arterial pressure by 10% to 20% during the first hour, then an additional 5% to 15% over the next 23 hours. follow. Initial dose is usually 1 to 2 mg/hour, double dose at 90-second intervals, as blood pressure approaches target, increase dose slowly every 5 to 10 minutes to achieve target blood pressure. pepper. Each dose increment of 1 to 2 mg/hour results in an additional 2 to 4 mm Hg reduction. The usual dose is 4 to 6 mg/hour. The average maximum dose was 21 mg/hour for 24 hours. Duration of Treatment: There is little experience with infusion times exceeding 72 hours at any dose. Patients should be switched to oral antihypertensives as soon as possible. This drug may be discontinued or the dose reduced during oral antihypertensive therapy. How to use:
Cleviprex is administered by intravenous infusion.
3. What are the side effects of Cleviprex?
Patients using Cleviprex may experience undesirable effects including:
Frequency > 10% : Cardiovascular: Atrial fibrillation. Gastrointestinal: Nausea. Frequency 1 to 10%: Gastrointestinal: Vomiting. Nervous system: Headache. Kidney: Acute kidney injury. Frequency <1%: Cardiovascular: Acute myocardial infarction, syncope, hypotension, tachycardia (reflex). Respiratory: Shortness of breath. Frequency unknown: Dermatology: Psoriasis. Endocrine and metabolic: Increased serum triglycerides. Gastrointestinal: Intestinal obstruction. Hypersensitivity: Hypersensitivity reaction. Respiratory: Decreased blood oxygen.
4. Notes when using Cleviprex
Before taking Cleviprex, tell your doctor if you have high cholesterol or triglycerides (especially if you also have pancreatitis), aortic stenosis (narrowing of the aortic valve in the heart), fatty kidneys (a disorder). kidney disorders), or if you are allergic to eggs or soy products. In an emergency, you can tell your caregivers about your health. Make sure any doctor who cares for you afterwards knows you have received this medicine. Hypertriglyceridemia: Clevidipine is formulated as a 20% fat emulsion therefore hypertriglyceridemia is an expected side effect of high-dose or prolonged treatment. Patients with hypertriglyceridemia are at risk for pancreatitis. Simultaneous reduction of lipid infusion may be necessary to compensate for lipid infusion. Patients may need to follow a special diet to reduce their fat intake. Follow all instructions given by your doctor or dietitian. Learn about foods to eat or avoid to help manage hypertriglyceridemia. Use is contraindicated in patients with defects in lipid metabolism (eg, pathological hyperlipidemia or acute pancreatitis if accompanied by hyperlipidemia). Cardiovascular effects: Systemic hypotension may occur. Blood pressure should be lowered at a rate appropriate to the patient's clinical condition. Reflex tachycardia may occur and may lead to angina or myocardial infarction in patients with obstructive coronary disease. In either case, reduce the dose of Clevidipine or discontinue if severe. Recurrent hypertension may occur with prolonged use in patients who are not switched to other antihypertensive therapy. Carefully monitor these patients for at least 8 hours after stopping the infusion. Heart failure: Dihydropyridine calcium channel blockers may worsen heart failure. Avoid use in patients with heart failure because of no benefit and/or worse outcome. Pregnancy: The available data based on post-marketing reports are insufficient to conclude on the risk of birth defects, drug-induced miscarriage, or adverse maternal or fetal outcomes. Therefore, caution should be exercised when using Cleviprex in pregnant women.
5. Drug interactions
Drug interactions can affect the effectiveness of the treatment and increase the unwanted effects of the drug. Therefore, patients should inform their doctor of all prescription and nonprescription drugs, supplements and vitamins they are taking for advice. The following are some interactions to watch out for when using Cleviprex:
Duloxetine : There may be an increased risk of orthostatic hypotension and syncope when Clevidipine is used in combination with Duloxetine. Levodopa: The risk of orthostatic hypotension may be increased when Clevidipine is combined with Levodopa. Risperidone: Clevidipine may increase the antihypertensive activity of Risperidone. Lomitapide: The metabolism of Lomitapide may be reduced when combined with Clevidipine. The article has provided information about the uses, dosage and notes when using Cleviprex. If you need more information or have any questions about Cleviprex, you should contact your doctor or pharmacist for advice.
