What is Guanethidine drug: Use and dosage

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Guanethidine is a drug commonly used mainly in the treatment of high blood pressure patients. It is available in the form of tablets, syringes, and eye drops. For more detailed information about the use and dosage of Guanethidine, please refer to the article below.

1. What is Guanethidine?

Guanethidine is a drug used to treat high blood pressure. Guanethidine may be used alone or in combination with other antihypertensive drugs.
1.1 Indications for the use of Guanethidine in patients with moderate and severe hypertension. Renal hypertension such as pyelonephritis. Renal amyloidosis and renal artery stenosis. Having some eye diseases such as open-angle glaucoma, endocrine protrusion, paralyzed eyes, difficult eyelids to open. 1.2 Contraindications People who are sensitive to any of the ingredients of the drug. The patient has been treated with monoamine oxidase inhibitors (MAOIs). Congestive heart failure Renal failure People with adrenal myeloma Pregnant or breastfeeding women.

2. Dosage of Guanethidine

Depending on the medical condition, each patient will be prescribed a different dose by the doctor. Accordingly, the specific dosage of Guanethidine is as follows:
2.1 Adult Dosage For outpatient treatment
Oral form : Initial dose 10 mg daily, then increase dose to 12.5 mg per day days, before increasing the dose need the consent of the doctor, do not increase the dose arbitrarily. The average is about 25-50 mg/day. Intramuscular form: Injection 10-20mg / time, the drug will be able to lower blood pressure within 30 minutes and be effective in about 1-2 hours. If hypertension persists, an additional dose of 10 - 20 mg can be given. 20 mg, however the interval between injections was increased to 3 hours. For inpatient treatment
Initial dose: 10mg/day. The dose can be increased to 400mg/day, however, when increasing the dose requires the consent of the doctor. Particularly for the elderly should take 5mg / day. Used in the treatment of eye diseases
Use eye drops, drop 1-2 drops/eye. Smaller 2 to 4 times a day. 2.2 Dosage for children Use an initial dose of 0.2 mg/kg/time/day. Maintain for 1-2 weeks. Use maintenance dose: Increase the dose equivalent to the initial dose up to 3mg/kg/day. However, to ensure the safety of children before increasing the dose, it is necessary to have the consent of the doctor, not to buy and use it yourself.

3. Instructions for use of Guanethidine

Read carefully the instructions for use before using, during the use of the drug, if there are abnormal symptoms, you need to stop using the drug and go to the nearest medical facility for examination
Take the correct dose; If you miss a dose, just take the next dose, do not take a double dose.

4. Guanethidine side effects

In the process of using the drug Guanethidine may cause some unwanted effects such as:
At the injection site, the skin is irritated, red, swollen, and pus appears; Weakness in the body, dizziness can even lead to fainting; Congestive heart failure; Heart rate slower than normal; Increased blood urea ; Loss of taste for food, loss of appetite with symptoms of vomiting; Inhibiting ejaculation, nocturia; There are symptoms of depression ... Not everyone who uses the drug also has side effects. However, when using Guanethidine, patients should not be subjective. Once you have the above signs, you should report it to your doctor so that you can have timely treatment plans to avoid complications.

5. Guanethidine drug interactions

There are some drugs that, when used in combination with Guanethidine, will increase the side effects and reduce the function of the drug. To limit possible drug interactions, tell your doctor if you are taking any medications.
Drugs that can interact with Guanethidine drugs such as:
Monoamine oxidase inhibitors: causing catecholamine release when used in combination with Guanethidine causing dangerous hypertension. Antiarrhythmic drugs and digitalis: Will cause severe arrhythmia symptoms. Concomitant use of guanethidine with other antihypertensive agents such as reserpine, methyldopa, vasodilators (especially minoxidil), beta-blockers and alcohol consumption will decrease the effect or activity of these drugs. Oral contraceptives. In addition, health conditions also affect the action of the drug, especially:
Patients with a history of stomach ulcers. Patients with a history of heart disease such as patients who have recently experienced a heart attack or stroke Are experiencing diarrhea. The patient is in the process of being treated for asthma, type 2 diabetes. Diarrhea Have diseases related to the liver and kidneys such as: Adrenal myeloma To limit the occurrence of side effects when using the drug, please Consult your doctor about your current health condition. Store the medicine Guanethidine at normal room temperature, do not store it in a humid place or in direct sunlight, it will make the drug lose its effectiveness.
For detailed information, please contact the hospitals and clinics of Vinmec health system nationwide.

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SEE ALSO
How to take oral antihypertensive drugs in combination Instructions for taking blood pressure medication correctly When is the best time to take blood pressure medication?