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Klacid 500mg is often used in the treatment of some bacterial infections such as pharyngitis, sinusitis, bronchitis, pneumonia, folliculitis,... So what is the use of Klacid 500mg and how to use it? How is this medicine?1. Uses of the drug Klacid 500mg
Klacid MR 500mg is made in the form of tablets, with the main ingredient being Clarithromycin 500mg, belonging to the group of Macrolide antibiotics. Klacid 500mg drug has a broad spectrum on both aerobic, anaerobic, spirochete bacteria, especially intracellular bacteria. The active substance Clarithromycin has antibacterial activity through binding to the 50S ribosomal subunit of susceptible bacteria and inhibiting their protein synthesis. Klacid 500mg is highly effective against many aerobic and anaerobic gram-positive and gram-negative bacteria.
The minimum inhibitory concentration of Clarithromycin is two times lower than that of Erythromycin. Accordingly, Klacid 500mg is indicated in the following cases:
Lower respiratory tract infections such as: Acute and chronic bronchitis, pneumonia. Upper respiratory tract infections such as sinusitis and pharyngitis. Skin and soft tissue infections such as folliculitis, cellulitis. Bacterial infection in teeth. The drug Klacid 500mg is contraindicated in the following cases:
People with hypersensitivity to any ingredient of the drug. Patients with a history of congenital or acquired QT prolongation, ventricular arrhythmias, including torsades de pointes. Hypokalemia (risk of QT prolongation). Patients with severe liver failure with renal failure. Patients with renal failure have creatinine clearance less than 30 ml/min. Klacid 500mg should be used with caution in the following cases:
Klacid 500mg should not be used in pregnant women before carefully weighing the benefits and risks, especially during the first 3 months of pregnancy. . As with other antibiotics, long-term use of Klacid 500mg may increase the proliferation of fungi and bacteria that are not susceptible to the drug. If superinfection occurs, appropriate therapy should be instituted. Be careful when using Klacid 500mg for patients with severe renal impairment. Stop using Klacid 500mg if you develop signs and symptoms of hepatitis such as loss of appetite, jaundice, dark urine, itching, or abdominal pain. Clarithromycin in Klacid 500mg is excreted mainly by the liver, so it should be used with caution in patients with impaired liver function.
2. Dosage and how to use Klacid 500mg
How to use Klacid 500mg as follows:
The drug is used orally. Do not study or chew the tablet. Take medicine with meals. Dosage of Klacid 500mg for adults and children over 12 years old is as follows:
The usual dose is 1 tablet/day. In more severe infections, the dose of Klacid 500mg may be increased to 2 tablets per day. The usual duration of treatment with Klacid 500mg is 5-14 days, except for community-acquired pneumonia and sinusitis requiring 6-14 days of treatment. Tooth infection: Use 1 tablet/day for 5 days. If you forget a dose of Klacid 500mg, take it as soon as you remember. If it is almost time for your next dose, skip the missed dose and take your next dose as usual.
Overdose of Klacid 500mg can cause gastrointestinal symptoms. Patients should treat allergic reactions associated with an overdose of Klacid 500mg by gastric lavage and supportive treatment.
3. Undesirable effects of the drug Klacid 500mg
When using Klacid 500mg you may experience common undesirable effects such as abdominal pain, diarrhea, nausea, vomiting and taste disturbance.
Common side effects of Klacid 500mg include:
Digestion: Taste disturbance, diarrhea, nausea, vomiting, stomach pain, indigestion. You can also have mild to life-threatening pseudomembranous colitis. Systemic: Hypersensitivity reactions such as itching, irritation, urticaria, skin rash. Nervous: Headache. Skin: Rash. The uncommon side effects of Klacid 500mg include:
Digestion: Occurrence of cholestasis symptoms such as upper abdominal pain, sometimes severe pain. Hepatic: Liver dysfunction, increased serum bilirubin and often accompanied by symptoms of jaundice, typhus and eosinophilia. Hearing: If taken in high doses can cause deafness, this condition is reversible. Other side effects of Klacid 500mg include:
Clostridium difficile enteritis. Increased alkaline phosphatase. Anaphylactic Anorexia. Anxiety, confusion, disorientation, hallucinations, seizures. Increased GGT Glossitis Hearing loss. Liver failure, hepatitis, hypoglycemia, elevated liver enzymes. Insomnia Prolong QT time Increase serum creatinine. Stevens-Johnson syndrome. Gastritis Thrombocytopenia Tongue discoloration, tooth discoloration, tremor. Ventricular arrhythmia, dizziness. If you experience any side effects when using Klacid 500mg, please inform your doctor immediately for timely treatment.
4. Interaction of Klacid 500mg with other drugs
Do not take Klacid 500mg with the following drugs due to the possibility of serious drug interactions: Cisapride, Ritonavir, Pimozide, Erectile Dysfunction Alkaloid, Oral Midazolam, Astemizole, Fluconazole, Colchicine, Digoxin,...
Klacid 500mg drug affects the metabolism and effects of some other drugs: Antiarrhythmics, Insulin, Omeprazole, Tadalafil, Sildenafil, Theophylline, Tolterodine, Triazolo Benzodiazepine, Itraconazole, Saquinavir, Carbamazepine,...
Klacid 500mg commonly used in the treatment of some bacterial infections such as pharyngitis, sinusitis, bronchitis, pneumonia, folliculitis, .. To ensure effective treatment and avoid side effects, patients need to take medicine according to prescription or consult a doctor, pharmacist for advice.
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