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Ampiryl 4mg drug has the main ingredient glimepiride 4mg, is made in the form of tablets. This is an active ingredient used in the treatment of type 2 diabetes, belonging to the sulfonylurea group. Let's find out useful information about Ampiryl drug through the article below.
1. What is Ampiryl 4mg?
Type 2 diabetes is a metabolic disease, caused by the body's resistance to insulin or the insufficient amount of insulin secreted by the beta cells in the pancreas, thus increasing blood glucose levels. glucose in the blood. The active ingredient glimepiride in Ampiryl 4mg has the ability to stimulate beta cells in the pancreas to increase insulin release, improve the sensitivity of peripheral tissues to insulin, and it also increases the number of glucose transporters through cell membranes, resulting in a decrease in blood glucose levels.
From the above mechanism of action, Ampiryl 4mg is used by doctors to treat patients with type 2 diabetes after controlling blood glucose by simply changing diet and exercise. . In addition, Ampiryl 4mg can also be used in combination with metformin, or insulin, or glitazone in the treatment of type 2 diabetes to varying degrees.
2. Dosage and how to use Ampiryl 4mg
Dosage of Ampiryl 4mg drug is determined based on blood glucose concentration, response and tolerance of each patient. The recommended starting dose is 1mg per day. After 1 to 2 weeks, if blood glucose is still not controlled, increase by 1mg/day.
Usually, the therapeutic dose of the patient ranges from 1 - 4mg per day. The maximum dose of Ampiryl is 8mg/day.
If Ampiryl 4mg is used for combination therapy with metformin or glitazone, it should be started with the lowest dose of each drug, and then gradually increased according to the patient's response to the dose until control is achieved. blood sugar.
In the course of using the drug, the patient needs to adjust the dose in the following cases:
When the patient's weight and activities change. When diabetes is under control, blood glucose levels are maintained at a stable level. Now that insulin sensitivity has been increased, consideration may be given to gradually reducing the dose of Ampiryl to the patient, in case of excessive hypoglycaemia. When patients use in combination with other drugs that increase or lower blood sugar. Patients were evaluated for impaired liver or kidney function. How to use Ampiryl 4mg is recommended as follows:
The drug is taken only once a day, the time of taking is 15 - 20 minutes before breakfast. Patients should take the tablet whole, without biting, chewing, or breaking the tablet. When you forget to take a medicine, do not make up for the missed dose on the next dose, to avoid overdose causing serious consequences.
3. Contraindications of Ampiryl 4mg
Ampiryl 4mg is contraindicated for the following subjects:
Patients with type 1 diabetes, also known as insulin dependent diabetes. Diabetic patients with acid-ketosis, coma, pre-coma, coma due to increased osmotic pressure or other acute diseases. Patients with severely impaired liver and kidney function. People who are pregnant, intend to become pregnant, or are breast-feeding, because Ampiryl has been determined to cause embryotoxicity. Patients with a history of hypersensitivity to glimepiride or the excipients in the drug. Patients with a history of allergy to sulfonamides.
4. Drug interactions
When using Ampiryl 4mg in combination with some of the following drugs, drug interactions may occur that change the effectiveness of treatment, so patients need to be careful and cautious.
Insulin, chloramphenicol, MAO inhibitors, non-steroidal anti-inflammatory drugs, probenecid, quinolone antibiotics, ACE inhibitors, beta channel blockers, sulphonamides, male sex hormones, drugs Other hypoglycaemia: These are drugs that have the potential to increase the hypoglycaemic effect of Ampiryl leading to excessive hypoglycemia, so a reduction in the dose of Ampiryl should be considered in the event of concurrent use. with the above drugs. Corticosteroids, thiazide diuretics, sympathomimetics, glucagon, estrogen-containing contraceptives, phenytoin, rifampicin, thyroid hormone, catecholamines: These are drugs that increase blood sugar when used in combination with Ampiryl 4mg leads to difficulty controlling blood sugar at a steady level. In this case, an increase in the dose of Ampiryl should be considered. Note, the dose increase or decrease in the above cases requires the consent of the doctor, the patient should not change the dose of Ampiryl 4mg on their own.
5. Undesirable effects when treated with Ampiryl 4mg
When patients are treated with Ampiryl 4mg, the following side effects may occur:
Hypoglycemia Dizziness, dizziness, dizziness Digestive disorders, epigastric discomfort, diarrhea, abdominal pain visual disturbances Increased liver enzymes, impaired liver function Decreased white blood cells, especially granulocytes, in addition, slightly decreased red blood cells and platelets. Increases light sensitivity of the skin. Hives, itchy rash. Among the undesirable effects mentioned above, low blood sugar is the most common. Symptoms of patients with mild hypoglycemia are shivering, sweating, heart palpitations, fatigue, dizziness, increased blood pressure, in more severe cases can cause confusion, confusion. aphasia, loss of consciousness leading to coma. In the case of only mild symptoms, the patient should drink a glass of water mixed with 20-30 grams of white sugar, monitor every 15 minutes until the blood sugar returns to normal. For more severe cases, the patient should be taken to the nearest medical facility for timely treatment.
Remaining side effects are often reported in rare degrees, these symptoms tend to decrease and disappear during treatment, if symptoms worsen and affect quality of life, Doctors may consider stopping the drug and switching to other regimens.
6. Notes when using Ampiryl 4mg
During the treatment of type 2 diabetes with Ampiryl 4mg, the patient must still maintain a reasonable diet and exercise to achieve the best blood sugar control effect. Patients may respond well to Ampiryl for a certain period of time, then the ability to respond to the drug decreases, the blood glucose level is no longer controlled, this is a common feature of the treatment drugs. If you have diabetes, you should consider changing your dose or using it in combination with other hypoglycemic agents. Patients should periodically check blood sugar with Hba1c test every 3 to 6 months to ensure the response to the drug. Stress, anxiety, stress, trauma, surgery can affect the ability of Ampiryl 4mg to control blood sugar, even if the patient has previously responded well. When increasing, decreasing the dose or changing the course of Ampiryl, the patient's blood sugar may become unstable, which affects the patient's reflexes and flexibility. Therefore, caution should be exercised if the patient is a driver of a train, vehicle, operator of machinery or working at height. People with liver failure, kidney failure, malnutrition, and hypopituitarism are often more sensitive to Ampiryl than other subjects, so it is necessary to monitor treatment to prevent hypoglycemia. Ampiryl 4mg drug has the main ingredient glimepiride 4mg, is made in the form of tablets. This is an active ingredient used in the treatment of type 2 diabetes, belonging to the sulfonylurea group. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to strictly follow the instructions of the doctor, professional pharmacist.
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