This is an automatically translated article.
17 - OH progesterone is 1 of the tests done to screen newborns by taking blood from the heels of babies 2 to 7 days old. This test is done to assess the risk of congenital adrenal hyperplasia in children, making treatment earlier and more effective.
1. 17-OH What is progesterone?
17-OH progesterone is an endogenous hormone secreted by the adrenal cortex in the chain that converts cholesterol into the hormones cortisol, aldosterone, and testosterone.
17-OH progesterone is a precursor to corticosteroids, which is used by the body to produce cortisol. Cortisol is a very important hormone for the body involved in the hydrolysis of proteins, fats, glucose, blood pressure regulation and the immune system in the body.
Cortisol production is catalysed by several enzymes, if one or more of the enzymes that catalyze this process is deficient or dysfunctional, there will be decreased production of cortisol and the 17-OH-Progesterone precursor form of cortisol will stasis in the blood. The adrenal glands then use the excess 17-OH-Progesterone in the blood to produce androgens. Excess androgens can cause virilization.
Deficiency of the enzyme that catalyzes the production of cortisol and an excess of androgens leads to a group of congenital adrenal hyperplasia disorders. Causes of congenital adrenal hyperplasia are often genetic with manifestations such as:
For girls: The genitals develop abnormally, are unclear, difficult to determine the sex at birth, childhood hirsutism, menstrual irregularities, and the appearance of virilization. For boys: Enlarged penis, larger than children of the same age, dark scrotum, early puberty. In addition, children appear symptoms such as vomiting, prolonged diarrhea, slow weight gain. Congenital adrenal hyperplasia (CAH) is rare, detected by clinical factors and by testing for 17-OH progesterone. However, in some cases of late onset, unknown manifestations are often overlooked. Therefore, screening newborns with 17-OH progesterone test is very important, contributing to the detection of congenital adrenal hyperplasia, which can significantly affect development, growth, and risk. adult infertility or even life-threatening loss of salt.
3. Newborn screening 17-OH progesterone test
17-OH-Progesterone test is a technique to help quantify the 17-OH-Progesterone index in the blood. This is one of the effective tests to screen newborns and diagnose congenital adrenal hyperplasia in children.
Newborns have a 17-OH-Progesterone test with a heel blood sample within 2 to 7 days after birth and before any symptoms of the disease.
In addition, the 17-OH-Progesterone venous blood test is also performed in children with suspicious signs or screening children who show a high risk of CAH.
After testing, the child's risk factors will be assessed based on a reference frame. For infants, the 17-OH Progesterone index reference threshold is usually different for each weight:
For infants weighing 2500 grams or more: 17-OHP index is less than or equal to 33 nmol/ L. For infants weighing 2500 grams or less: The 17-OHP index is less than or equal to 30 nmol/L. If the test index is greater than the normal values, then the child is at risk of congenital adrenal hyperplasia, it is necessary to conduct other tests to confirm the diagnosis and then have early and effective treatment measures. fruit.
Xét nghiệm 17-OH-Progesterone rất hữu hiệu để sàng lọc sơ sinh và chẩn đoán bệnh tăng sản thượng thận bẩm sinh ở trẻ nhỏ
4. Meaning of 17-OH progesterone test
There are many cases of children showing signs of late CAH, affecting the effectiveness of treatment. Therefore, testing for 17-OH-Progesterone is an effective method with the aim of early detection of subjects at risk of congenital adrenal hyperplasia, thereby providing treatment methods to limit levels the danger of the disease to the development of the child. Once the disease is detected, the treatment depends on the signs such as: For those with loss of salt, the diet needs to increase the amount of salt in food more than the average person, supplementing with water and minerals regularly, Helps to stabilize and balance the body. For children with precocious puberty, during treatment, doctors can use drugs to lower androgen hormone levels and supplement cortisol hormone. For children with abnormal genitalia, surgery is needed to correct and re-adjust the genitals. In summary, the 17-OH progesterone test can screen for congenital adrenal hyperplasia, help early detection and effective treatment. Parents should carefully study this test to be able to best screen their baby. The implementation of newborn screening is not only an individual matter of any family, but a long-term step for the population in particular and the whole society in general for the purpose of improving and raising the quality of the breed and the health of the population. prosperity of society, towards a future that minimizes disability caused by congenital diseases. Currently, the Pediatrics Department at Vinmec International General Hospital is the address to receive and examine the diseases that babies and children are susceptible to, trusted by many parents. Vinmec brings satisfaction to customers and is highly appreciated by industry experts by::
Gathering a team of leading pediatricians: including leading experts with high professional qualifications. (professor, associate professor, doctorate, master), experienced, worked at major hospitals such as Bach Mai, 108.. The doctors are well-trained, professional, conscientious - understanding and understanding young psychology. In addition to domestic pediatric specialists, the Department of Pediatrics also has the participation of foreign experts (Japan, Singapore, Australia, USA) who are always pioneers in applying the latest and most effective treatment regimens. . Comprehensive services: In the field of Pediatrics, Vinmec provides a series of continuous medical examination and treatment services from Newborn to Pediatric and Vaccine,... according to international standards to help parents take care of their baby's health from birth to childhood. Advanced techniques: Vinmec has successfully deployed many specialized techniques to make the treatment of difficult diseases in Pediatrics more effective: neurosurgery - skull surgery, stem cell transplantation blood in cancer treatment. Professional care: In addition to understanding children's psychology, Vinmec also pays special attention to the children's play space, helping them to play comfortably and get used to the hospital's environment, cooperate in treatment, improve the efficiency of medical treatment.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
