Uses of Trikaxon

Trikaxon is an injectable antibiotic with the active ingredient Ceftriaxon. The drug is used by intramuscular injection or intravenous infusion for severe infections caused by bacteria sensitive to Ceftriaxone.

Trikaxon 1g drug contains ceftriaxone (in the form of ceftriaxone sodium) with a concentration of 1000mg and other excipients, just enough for 1 vial. The drug is in the form of a powder for injection. Ceftriaxone is a 3rd generation cephalosporin antibiotic with broad spectrum antibacterial activity. The mechanism of action is similar to that of other antibiotics, which is to inhibit bacterial cell wall synthesis by binding to one or more penicillin-binding proteins (PBPs), inhibiting at the final step of synthesis. cell wall. Ceftriaxone is stable to bacterial beta lactamases, so it is active against a wide range of gram-negative and gram-positive bacteria.
Ceftriaxone, if taken orally, is not absorbed from the gastrointestinal tract, so it is mainly used intravenously or intramuscularly. The drug can achieve an intramuscular bioavailability of 100%. Widely distributed in tissues and body fluids and may be excreted across the placenta, into breast milk.

Indications:
Trikaxon is indicated for use in severe infections caused by bacteria sensitive to Ceftriaxon including:
Meningitis, except for Listeria. Lyme disease ; Genitourinary tract infections including pyelonephritis, cystitis and urethritis. Severe respiratory tract infections such as pneumonia, purulent tonsillitis, otitis media... Bacterial infections caused by gonorrhea, typhoid, syphilis; Sepsis, bone and joint infections, skin infections. Prophylaxis of infection in surgical, laparoscopic interventions such as vaginal or abdominal surgery. Contraindications:
Contraindicated to use Trikaxon with hypersensitivity to Ceftriaxone or other cephalosporins, to any other excipients. Use with caution in patients with a history of anaphylaxis to penicillins because of the risk of cross-allergic reactions. For intramuscular injection: Do not use if sensitive to lidocaine, not for children under 30 months.

3.1 How to take Trikaxon The drug is used by intramuscular or intravenous injection, the use of the drug should be done by medical personnel. Mixing solution for injection is done as follows:
Solution for intramuscular injection: Use 1 vial of Trikaxon dissolved with 3.5ml of 1% lidocaine solution. At the same site, do not inject more than 1g intramuscularly. Do not use injection solutions containing lidocaine for intravenous administration. Intravenous solution: Use 1 vial of Trikaxon dissolved in 10ml of sterile distilled water. Inject slowly over a period of 2-4 minutes. Injected directly into a vein or through a solution infusion line. Solution for infusion: Use this route when taking high doses. Mix 2g of soluble powder with 40ml of calcium-free infusion solution such as 0.9% sodium chloride solution, 5% glucose solution, 10% glucose solution or other solution. Do not use Ringer lactate solution to dissolve drug powder for infusion. Minimum transmission 30 minutes. Keep the drug Trikaxon in a dry place, away from direct light and at a temperature not exceeding 30 degrees Celsius. The solution after mixing with distilled water for injection can be kept stable for 2 days at room temperature 25 -27 degrees C or 10 days at a temperature of about 5 degrees C. Solutions after mixing with 1% Lidocaine can be kept for 24 hours at room temperature 25 -27 degrees C or 3 days at 5 degrees C. 3.2 Dosage Trikaxon medicine Adults and children over 12 years old: The usual dose is 1-2g per day, injected once or can be divided equally into 2 times. In severe cases, the dose can be up to 4g/day.
To prevent intraoperative infection, a single intravenous dose of 1g is given 0.5 - 2 hours before surgery.
Children under 12 years old: Daily dose is about 50 - 75mg/kg body weight, injected once or divided equally into 2 times. The total dose in children should not exceed 2g/day.
In the treatment of meningitis, the starting dose is 100mg/kg (do not exceed 4g). After that, the total daily dose is 100 mg/kg/day, injected once a day.
Treatment time is usually 7-14 days. For infections caused by Streptococcus pyogenes, treatment should be at least 10 days.
Newborns: Use at a dose of 50mg/kg/day.
Combined renal and hepatic impairment: Adjust dose based on creatinine clearance. When creatinine clearance is less than 10ml/min, the dose of ceftriaxone should not exceed 2g/24 hours.
Hemodialysis A dose of 2g administered at the end of dialysis is sufficient to maintain effective drug concentrations until the following dialysis session, usually for 72 hours.

When using Trikaxon you may encounter side effects including:
Pain, burning sensation at the injection site; Headache, dizziness, sweating, hot flashes; Diarrhea, rash, bloody stools, fever, stomach cramps, stomach pain or bloating, nausea and vomiting, heartburn; Chest tightness; Mild to severe hypersensitivity reactions may also occur. Increased liver enzymes, jaundice, acute renal failure, interstitial pneumonia. Trikaxon may also cause other side effects not listed above. Tell medical staff immediately when unwanted effects occur, especially when injecting, if you see an abnormality, you need to report it immediately.

Because the drug is given by injection, it is necessary to carefully check the patient's allergy history before administering the drug. Test your skin for an allergic reaction before taking antibiotics.
It is necessary to check the liver and kidney function before taking the drug to ensure safe use of the drug.
When used, do not mix with other drugs, do not infuse with other lines containing drugs containing calcium.
Antibiotics are used only for bacterial infections or prophylactically when there is a high risk. Generally, parenteral antibiotics should only be indicated when there is a serious infection and oral administration is ineffective.
Trikaxon can cross the placenta and the breast milk barrier. Therefore, it is restricted to pregnant and lactating women. Before using it, consult your doctor to carefully weigh the benefits and risks. Should be avoided for women in the first 3 months.
Drug interactions: Some drugs can cause interactions such as Gentamicin, colistin, furosemide that can increase the possibility of nephrotoxicity; Probenecid may decrease renal clearance thereby increasing plasma concentrations of Trikaxon.
Trikaxon injection should only be used for severe infections that have not responded to other oral antibiotics. You need to be used under the doctor's prescription and if there is an abnormality, you need to report it immediately for timely treatment.