Uses of Tobadexa eye drops

Tobadexa is an eye drop suspension containing dexamethasone 0.1% and tobramycin 0.3%. Among them, tobramycin is a strong bactericidal aminoglycoside antibiotic and helps kill bacteria by inhibiting polypeptide synthesis on ribosomes. For dexamethasone has anti-inflammatory effects, inhibiting vascular endothelial cell adhesion molecules, cytokines or cyclooxygenase I or II.
Tobadexa is used in the prevention and treatment of infections associated with cataract surgery in children 2 years of age and older and in adults with steroid-responsive inflammatory eye conditions. and corticosteroids are indicated or when there is a superficial bacterial infection of the eye or there is a risk of ocular infection. Steroid eye drops are indicated in conditions of blepharitis and ocular conjunctivitis, or anterior segmental inflammation or keratitis when the patient accepts the inherent risks of steroid use to reduce inflammation and edema. In addition, Tobadexa is also indicated for use in cases of chronic anterior uveitis and corneal damage caused by radiation, chemicals or thermal burns, due to foreign bodies.
Treatment of a mixed drug with an anti-infective component is indicated when there is a high risk of common ocular infections such as:
Staphylococci including S.epidermidis and S.aureus including strains resistant to penicillin . Streptococci include several types of group A hemolytic streptococcus and a few non-hemolytic strains, streptococcus pneumoniae. Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Enterobacter aerogenes, Proteus mirabilis, Morganella morganii, most strains of Proteus vulgaris, Haemophilus influenzae and H. Aegyptius, Moraxella lacunata, and Acinetobacter calcoaceticus and some Neisseria vaginas (Herellea Neisseria vagina) In addition, some other effects of the drug are not listed on the approved drug label, but in some cases, the doctor may prescribe Tobadexa to be used. Therefore, before taking the medicine, consult your doctor.

Tobadexa medicine is prepared in the form of eye drops. Before use, shake the vial well. The patient should gently close the eyelid and block the lacrimal gland within 1 minute of instillation. To avoid contaminating the medication, be careful not to let the tip of the dropper touch the eyelids and surrounding or other surfaces of the vial, and close the cap immediately after not using it. Dosage will be based on the condition and age of the patient.
Instill 1-2 drops in the same conjunctiva every 4-6 hours. Within the first 24-48 hours the dose can be increased to 1-2 drops every 2 hours. The number of instillations should be gradually reduced as clinical signs improve, but treatment should not be stopped too early. Continue treatment for 14 days and not exceed 24 days. To use the medicine safely, use Tobadexa drops exactly as directed by your doctor, do not use more, smaller or longer than prescribed. Use Tobadexa regularly to get the most benefit from it and you can stop taking it if any new symptoms appear or your condition does not improve after 7 days. Patients absolutely do not abuse the drug for too long for a long time. This does not make the patient's condition better, but also increases the risk of unwanted effects.

Tobadexa medicine can cause some unwanted and common side effects, which can be mentioned as:
Eyelid edema Erythematous erythema of the eyelids Dilated pupils Increased tear production Erythema multiforme Rash, swelling and itching of the face Nausea and abdominal discomfort Cushing's syndrome Adrenal suppression Laryngeal spasm Headache Runny nose Eye pain, eye itching and eye discomfort Glaucoma Conjunctival edema Eye irritation Rare side effects may include such as keratitis, digestive disorders, blurred vision, dry eyes, eye allergies. Before prescribing medicine, doctors always consider the benefits and effectiveness of Tobadexa. When using Tobadexa can still occur unwanted effects. Therefore, when unusual symptoms are present, especially when a severe allergic reaction occurs with accompanying signs such as severe dizziness, difficulty breathing, rash, anxiety, cognitive impairment , respiratory failure and coma, the patient should immediately notify the doctor or nurse for immediate medical intervention.

Some notes when using Tobadexa include:
Allergy notice to Tobadexa hypersensitivity reaction to any other allergy. Tobadxa may contain inactive ingredients and could cause an allergic reaction or other serious problems. Report any medications you are taking including prescription and nonprescription drugs, herbal and dietary supplements, foods, dyes or preservatives. Tobadexa is contraindicated in patients with herpes simplex keratitis, untreated purulent eye infections, recent vaccinations or patients with chickenpox or other viral diseases of the cornea and conjunctiva, mycosis or eye infections caused by untreated parasites, mycobacterium leprae, mycobacterium tuberculosis, or mycobacterium avium eye infections. In women during pregnancy, animal studies have shown reproductive toxicity following systemic use of tobramycin and dexamethasone. Prolonged or repeated use of corticosteroids during pregnancy is associated with an increased risk of intrauterine growth retardation. Mothers who have used drugs with significant doses of corticosteroids during pregnancy and childbirth, the infant should be carefully monitored for signs of adrenal insufficiency. For nursing women, there have been no studies on whether tobramycin and dexamethasone are excreted in breast milk following topical application of eye drops, but a risk to the nursing infant cannot be excluded. Therefore, the drug should only be used when absolutely necessary. During treatment with Tobadexa may cause side effects such as temporary blurred vision or other visual disturbances that affect the ability to drive and use machines or activities that require alertness and concentration. central. Therefore, caution should be exercised in this case. Prolonged use of topical corticosteroids may increase intraocular pressure, lead to optic nerve damage and decreased visual acuity, as well as visual field defects and subcapsular cataracts. Therefore, it is necessary to pay attention to some side effects such as blurred vision, visual disturbances, glaucoma, Cushing's syndrome, adrenal suppression, secondary infection, perforation in people with thin sclera and cornea. . Tobadexa should be used with caution in patients with known or suspected neuromuscular disorders such as myasthenia gravis or Parkinson's disease. During treatment should avoid contact with soft contact lenses, should not wear contact lenses while treating infectious or inflammatory diseases of the eye. If the patient is allowed to wear contact lenses, wait at least 15 minutes before reinserting them. If you forget to drop a dose of Tobadexa, take it again as soon as possible. However, if it is close to the time of your next dose, skip the missed dose and continue as usual. Do not use more drug than the treatment regimen. Tobadexa overdose or ingestion can cause serious symptoms such as nausea, vomiting, abdominal pain, difficulty breathing, fainting,... In case of overdose, rinse eyes with warm water and Immediately go to the nearest medical facility.

Drug interactions can decrease the effect of Tobadexa, or increase the effect of unwanted effects. Tell your doctor about all other medicines you are taking including over-the-counter medicines, vitamins, prescription drugs, and herbal products. Do not start, stop or change the dose of any medicine without your doctor's consent.
Some drugs that can interact with Tobadexa such as CYP3A4 inhibitors including cobicistat and ritonavir: because they decrease the clearance of dexamethasone. In case of concurrent treatment with other ophthalmic products, an interval of at least 5 minutes should be allowed between applications.

Store Tobadexa in the form of eye drops at 8-27 degrees Celsius, protect from light and avoid humid places. Do not store Tobadexa in a humid place or in the freezer and keep away from heat and open flames. Different medicines will have different storage methods, so read the Tobadexa storage instructions carefully on the package, or ask your pharmacist. Keep Tobadexa out of the reach of children and family pets. When the medicine has expired or is damaged and cannot be used anymore, dispose of it and dispose of it properly. Do not arbitrarily dispose of Tobadexa into the environment such as a water pipe or toilet unless requested to do so. Please consult with your waste disposal company or pharmacist on how to safely dispose of Tobadexa to help protect the environment.
In summary, Tobadxa is effective in the prevention and treatment of infectious diseases associated with cataract surgery in children 2 years of age and older and in adults, inflammatory eye conditions that respond to cataract surgery. If there is a steroid response and corticosteroids are indicated, or when there is a superficial bacterial infection of the eye, there is a risk of ocular infection. Ophthalmic steroids are indicated for conditions such as blepharitis and conjunctival blepharitis, or anterior segmental inflammation or keratitis, etc. However, Tobadxa may cause some side effects. unwanted effects and drug interactions, so tell your doctor what medicines you are taking to reduce the risk of unwanted effects and at the same time increase the effectiveness of the treatment process.
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