Uses of Papaverin 40mg

What is papaverin? Papaverin is a drug that belongs to the Benzyl isoquinoline class of drugs. The drug is extracted from the poppy plant and discovered by a German scientist. Papaverin is available in the form of tablets, capsules and solution for injection. Accordingly, Papaverin inhibits smooth muscle contraction by:
Inhibits oxidative phosphorylation Inhibits calcium channels, inhibits muscle contractions and increases cAMP. The active ingredients in Papaverin have little CNS depressant effect, so the drug has no analgesic effect.
Pharmacokinetics
Absorption: Papaverin is readily absorbed from the gastrointestinal tract. Accordingly, in its rapid-acting form, Papaverin can also be formulated in an extended-release form and can last for up to 12 hours. Distribution: After absorption, papaverin is poorly distributed into tissues. Accordingly, the binding rate to plasma proteins is high (about 90%). Metabolism: Papaverin is metabolised in the liver by liver enzymes, eg CYP3A4, CYP2C9. Elimination: Papaverin is extensively excreted in the urine as glucuronic conjugates. The half-life is about 0.5 to 1.5 hours.

2.1. Indications of Papaverin Drug Papaverin has a direct inhibitory effect on smooth muscle spasms. Therefore, the drug Papaverin is usually prescribed by doctors in the following cases:
Patients with gastrointestinal smooth muscle spasms, Abdominal pain due to stomach and intestinal spasms, spasms of the biliary tract 2.2. Papaverin is contraindicated in the following cases:
Patients with complete atrioventricular block. Patients with hypersensitivity or allergy to any of the ingredients of Papaverin. People with Parkinson's disease.

In each dosage form of Papaverin, there will be different treatment:
For oral administration:
Adults: Each dose is from 40 to 100mg, used about 2 to 3 times a day.
For the case of needing long-term effects, use extended-release tablets at a dose of 150mg, take 1 tablet each time, use the drug twice a day.
For parenteral route:
Adults: Use the dosage of Papaverin from 30 to 120mg depending on the specific case. After about 3 to 4 hours, give the next dose, which can be administered intramuscularly or intravenously. For children: Use with a dose of Papaverin from 4 to 6 mg/kg, body weight every 24 hours divided into 4 times, can be administered intramuscularly or intravenously. It should be noted that when using the injection route, it is necessary to inject slowly over a period of 2 to 3 minutes to avoid causing cardiac arrhythmias, even death.

During the use of Papaverin, patients may experience some side effects as follows:
Effects on the central nervous system: Headache, dizziness, dizziness Effects on the digestive system: Digestive disorders , Vomiting, Diarrhea, Constipation, Liver dysfunction, Hepatitis due to toxicity of active ingredients in papaverin. The most dangerous side effects that can be encountered when using Papaverin are arrhythmias, respiratory arrest, and even the risk of death when using rapid intravenous injection. Therefore, if in the process of using the drug, the patient encounters any side effects, it is necessary to immediately go to the medical center for examination and appropriate treatment.

In the process of using Papaverin, patients should pay attention to the following issues:
People with glaucoma, hepatitis, liver dysfunction need to adjust the dose to suit their condition. health. When using the drug by intravenous route, it is necessary to be very careful, because if injected quickly, it can cause respiratory arrest and cause cardiac arrhythmias, even increase the risk of death. Can I use Papaverin for pregnant women? According to experts, it is necessary to carefully weigh the benefits and risks of using Papaverin for pregnant and lactating women. Therefore, it is best for these subjects to use the drug only when prescribed by a doctor and closely monitored by medical staff.

During use, Papaverin may cause drug interactions with other drugs and functional foods, specifically:
Papaverin reduces the effect of Levodopa by blocking receptors Dopamine body. Thereby, significantly reducing the therapeutic effect of Levodopa in Parkinson's disease. Although Papaverin has little effect on central nervous system depression, it has a synergistic effect with Morphine. Therefore, when used concurrently will increase central nervous system depression Papaverin is metabolized by liver enzymes. Therefore, drugs that inhibit liver enzymes such as antibiotics of the macrolide group: azole antifungal drugs such as itraconazole, clarithromycin,... will interact and affect the treatment process.

An overdose of Papaverin can cause serious side effects, even an increased risk of death. Some signs of drug overdose that patients can detect are as follows:
Nausea, Vomiting, Dizziness, Sweating, Muscle weakness, Vasomotor disturbances, Cardiac arrhythmias, Breathing and cardiac arrest. When a patient shows any of the above symptoms, they should immediately go to the nearest medical facility for timely treatment.
When dealing with overdose, it is necessary to protect the patient's airway, give artificial respiration if necessary. If the patient has convulsions, sedation and anesthesia should be used.
In oral form, if the patient forgets a dose, it should be taken as soon as he remembers, however, if it is almost time for the next dose, skip the missed dose and take the new dose as usual. Never take a double dose to make up for it.
In summary, Papaverin drug whose main ingredient is Papaverine hydrochloride is indicated for the treatment of a number of gastrointestinal diseases such as smooth muscle spasms, stomach spasms. To ensure effective use and avoid unwanted side effects, patients need to take the drug according to the prescription or consult a doctor, professional pharmacist.
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