This is an automatically translated article.
Mesalazine medicine has ingredients containing 5 aminosalicylic acid, 5-ASA content 500mg. The drug belongs to the group indicated for the treatment of ulcerative colitis, especially cases of sigmoid colitis, proctitis.
1. What active ingredients does Mesalazine 500 mg have?
Mesalazine 500 mg drug has ingredients including 5 aminosalicylic acid 5-ASA which have anti-inflammatory effects in the digestive tract. Mesalazine's mechanism of action has not been clearly demonstrated so far, however, the drug is still considered to have a local effect during treatment, not a systemic effect.
2. Indications and contraindications of Mesalazine 500 mg
2.1. Indications Mesalazine 500mg Mesalazine is indicated for use in the following cases: treatment of mild to moderate late-stage ulcerative colitis, treatment of sigmoid colitis, proctitis.
2.2. Contraindication to Mesalazine 500mg Mesalazine is contraindicated in some cases such as: Patients with a history of hypersensitivity to the salicylic or sulfasalazine components of the drug, People with severe renal failure Liver dysfunction, pyloric stenosis, obstruction intestine . In particular, the drug is contraindicated for children under 2 years of age.
3. Dosage and usage of Mesalazine
Mesalazine is made in the form of film-coated tablets, so it should be taken orally. When taking the drug, the patient should note that the tablet should be swallowed whole, not chewed or crushed before taking it.
Dosage for adults
Mesalazine acute treatment dose for adults: Use 4 grams equivalent to 8 tablets of 500mg/day and divided into 2 to 3 times. For maintenance therapy, initially use a starting dose of 1.5 grams, equivalent to 3 tablets of 500 mg/day and divided into 2 to 3 times/day.
Dosage for children
Dosage of Mesalazine for children with the following cases:
Treatment of ulcerative colitis: children from 5 to 15 years old use a maximum dose of 1 gram equivalent to 15 to 20 mg and use use 3 times a day. Children from 15 to 18 years of age use 1 to 2 grams corresponding to 2 to 4 Mesalazine tablets, twice a day or the total daily dose can be divided into 3 times
Maintenance treatment of ulcerative colitis and Crohn's disease: children from 5 to 15 years old use 10mg/kg with a maximum dose of 500mg divided into two times a day Children from 15 to 18 years old use 2g/time and use once a day. Special attention, Mesalazine drug is not suitable for children from 2 to under 5 years old, it is best to consult a doctor before use.
Currently, there is no recommended pharmacokinetic dose suitable for patients over 65 years of age. Therefore, elderly people need to be very careful when using Mesalazine.
The above drug dosage is for reference only. If the patient needs to be treated with Mesalazine, they should carefully study the information of the drug, and ask for the advice and prescription of the doctor.
4. Dealing with overdose and missed doses of Mesalazine
In case the patient forgets to take the medicine, take the missed dose as soon as he remembers. However, if the missed dose is close to the next dose, the patient can skip the missed dose and take the next dose. Do not take a double dose if you miss a dose. This can cause unwanted effects when used in excess.
5. Unexpected side effects when using Mesalazine
Common side effects: Body aches, headache, weakness, dizziness, fever, digestive disorders, diarrhea, nausea, abdominal pain or may increase symptoms of colitis, apple constipation, indigestion. Some patients may experience urticaria, rash, itching, acne, sore throat, cough... Rare side effects: Patients may also experience some rare side effects such as: Myositis heart , pericarditis , photosensitivity , hepatitis , increased transaminase , occurrence of arthralgia , cramps , back pain , or related neurological diseases , nephritis , nephrotic syndrome , . .. When the patient experiences unwanted side effects, they should stop using the drug and notify the doctor for timely treatment.
6. Some notes when using Mesalazine
When using Mesalazine, caution should be exercised in patients with impaired liver function or renal failure. Mesalazine is not recommended for patients with renal insufficiency, so regular monitoring of renal function with quantitative serum creatinine is required in the early stages of treatment. Using Mesalazine for diseases with unexplained bleeding or cases with bruises or purpura, anemia, fever... need to monitor hematological indicators For people with myocarditis and pericarditis component of the drug is noted should be used with caution. In case of suspected undesirable side effects, treatment should be discontinued. Mesalazine containing sulfasalazine in oral form may increase the risk of nephrotoxicity, and should be used with caution when used with other drugs during treatment.
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