Uses of Hismedan

Hismedan is a drug that helps hypoxic cells reduce oxygen consumption, so it reduces the symptoms of angina, and prevents the risk of angina. Let's find out more information about Hismedan drug through the article below.

Hismedan medicine 20mg has the main ingredient is Trimetazidine 20mg, is made in the form of film-coated tablets. Trimetazidine inhibits beta oxidation of fatty acids by inhibiting 3-ketoacyl-CoA long-chain enzymes. thiolase in ischemic cells, since glucose oxidation requires less oxygen consumption than beta oxidation. Inhibition of beta oxygen will promote glucose oxidation to help optimize cellular energy processes, thereby maintaining proper energy metabolism during periods of ischemia.
Thanks to that, this drug is used in the following cases:
Prophylaxis of angina pectoris. As an adjunct to symptomatic therapy in patients with uncontrolled stable angina. Patients with angina who are intolerant to other angina treatments. Following oral administration, the drug is rapidly absorbed and reaches peak plasma concentrations 2 hours after oral administration. Trimetazidine is mainly excreted in the urine as unchanged drug. The half-life of trimetazidine is 6 hours.
On the other hand, Hismedan 20mg is contraindicated in the following cases:
History of hypersensitivity to the active ingredient Trimetazidine or any of the excipients listed in the product formula Patients with Parkinson's disease or have Parkinson's symptoms, tremor, restless legs syndrome and other related movement disorders Patients with severe renal impairment (with creatinine clearance < 30 mL/min) because of renal excretion of the drug.

The drug is taken orally, should be taken with water and be careful not to chew or crush the tablet before taking it. The recommended dose of the drug is as follows:
The usual dose for adults is 1 tablet of Hismedan mooic once and taken 3 times a day, taken with meals. Patients with moderate renal impairment with creatinine clearance 30-60 mL/min: The recommended dose is 1 tablet twice daily, morning and evening, with meals. Elderly patients (may increase sensitivity to trimetazidine to a higher than normal range due to age-related decline in renal function): For patients with moderate renal impairment, the recommended dose is 1 tablet/time and Twice a day, morning and evening, with meals. Care should be taken when calculating the dose for elderly patients. Children: The safety and effectiveness of Hismedan in patients under 18 years of age have not been evaluated. There are currently no data on this patient population, so it should not be used. In case of possible overdose and in case of overdose you should induce vomiting, then take the patient to the nearest medical facility for appropriate treatment
If you miss a dose, take the medicine as soon as possible good. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time.

When using Hismedan, as well as other drugs, you may experience unwanted effects:
Common unwanted effects include: Dizziness, headache, abdominal pain, diarrhea, indigestion, nausea and vomiting, allergies cause rash, itching, urticaria, body weakness. Rare: Palpitations, palpitations, tachycardia, extrasystoles, arterial hypotension... In addition, patients may experience some other side effects such as: Constipation; exanthema, acute generalized pustulosis (AGEP), angioedema; agranulocytosis...
When experiencing side effects of the drug, you need to stop using it and notify your doctor or if it is serious, you need to go to the nearest medical facility for timely treatment.

Before using the drug, you need to carefully read the information on the instructions for use, notify the doctor if you are allergic or have other medical conditions.
Use caution when using for women who are pregnant or breastfeeding, should weigh the effect and risk. Since the extent of the effects is unknown, it is best not to use trimetazidine as it may cause or worsen Parkinson's symptoms (tremor, slowness of movement and difficulty walking, increased muscle tone). Therefore, before use, patients, especially elderly patients, should be examined and monitored regularly. In cases of suspected parkinsonism, the patient should be discontinued and referred to a neurologist for appropriate examination. Traumatic falls, unsteady gait, or hypotension may occur, especially in patients receiving concomitant antihypertensive drugs. Caution should be exercised when prescribing trimetazidine to patients with a high degree of sensitivity to the drug, such as patients with moderate renal impairment, patients over 75 years of age. Hismedan may cause dizziness and drowsiness, so taking it may affect the ability to drive and use machines, care should be taken when doing this. Drug Interactions: Currently, there are no known interactions of this drug with any other drugs. Trimetazidine is not an inhibitor of drug-metabolizing enzymes in the liver. Thus, trimetazidine does not interact with many drugs metabolized in the liver. However, careful monitoring is still required when combining Hismedan with another drug. Hismedan is used under the prescription of a doctor, so you should not use it on your own. Hopefully, through the article, you have understood more about Hismedan and if you have any questions, please consult your doctor or pharmacist.