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Chloramphenicol 250mg is used to treat severe infections caused by susceptible bacteria. In order to use the drug effectively, patients need to learn some information about the uses, dosage and notes when using Chloramphenicol 250mg in the article below.1. What is Chloramphenicol 250mg?
Chloramphenicol 250mg is a drug for the treatment of many serious infections caused by susceptible bacteria, Rickettsia, Chlamydia when less toxic drugs are ineffective or contraindicated.
The drug is prepared in the form of hard capsules, packing box of 10 blisters x 10 tablets. This is a prescription drug, so patients only use Chloramphenicol 250mg when prescribed by a doctor.
2. Dosage of Chloramphenicol 250mg
Adults:
Use dose of Chloramphenicol 1-2g/day, divided into 4 times. Children:
Use dose of Chloramphenicol 50mg/kg/day, divided into 4 times. The above dose of Chloramphenicol 250mg is for reference only. The specific dose of Chloramphenicol will depend on the condition and the progression of the disease. To get the right dose of Chloramphenicol, patients need to consult their doctor/pharmacist.
3. Contraindications to using Chloramphenicol 250mg
Do not use Chloramphenicol 250mg in the following cases:
People who are sensitive to Chloramphenicol; Chloramphenicol 250mg is contraindicated for the treatment of common bacterial infections or as a prophylactic agent. Contraindications are understood as absolute contraindications. It is not for any reason that contraindications can be flexible to use Chloramphenicol 250mg.
4. Note when using Chloramphenicol 250mg
During the use of Chloramphenicol 250mg, the following should be noted:
Serious, sometimes fatal reactions may occur in patients receiving Chloramphenicol 250mg; When the index of reticulocytes, white blood cells, platelets is decreased, anemia or other hematological abnormalities, it is necessary to immediately stop taking Chloramphenicol 250mg; Discontinue chloramphenicol 250mg if optic or peripheral neuritis occurs. Chloramphenicol 250mg should be used with caution in people with impaired kidney/liver function.
5. Undesirable effects when using Chloramphenicol
During the use of Chloramphenicol 250mg, patients may encounter some of the following side effects:
Common side effects: Nausea/vomiting, diarrhea and rash; Uncommon side effects: Agranulocytosis/platelets, anemia, urticaria, hypersensitivity reactions; Rare side effects: Headache, non-regenerative anemia, agranulocytosis, optic neuritis and peripheral polyneuropathy, neonatal gray syndrome. During the course of treatment, if any abnormal symptoms appear due to the use of Chloramphenicol 250mg, the patient should notify the treating doctor for timely treatment.
6. Interactions with other drugs
Possible interactions when using Chloramphenicol 250mg simultaneously with the following drugs:
Chloramphenicol 250mg destroys the cytochrome P450 enzyme in the liver (responsible for the metabolism of many drugs); Chloramphenicol 250mg may affect the metabolism of Dicumarol, Phenytoin and Tolbutamide by inhibiting the activity of microsomal enzymes, thereby increasing the effects of these drugs; Concomitant administration of Chloramphenicol 250mg and Phenobarbital may decrease the antibiotic plasma concentration. The reason is that Phenobarbital induces P450 enzyme capable of destroying Chloramphenicol; Chloramphenicol 250mg may slow the response when used concurrently with iron preparations, vitamin B12 or folic acid; Concomitant use of Rifampicin reduces the plasma concentration of Chloramphenicol; Avoid concomitant use of Chloramphenicol 250mg with drugs that cause bone marrow depression. To avoid unwanted interactions when using Chloramphenicol 250mg, patients should inform their doctor/pharmacist of all medications, dietary supplements, vitamins they are taking.
Above is information about uses, doses and precautions when using Chloramphenicol 250mg. To ensure safety for your health and maximize the effectiveness of your treatment, you need to take Chloramphenicol 250mg exactly as directed by your doctor.
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