This is an automatically translated article.
Posted by Doctor CKII Bui Thu Huong - Head of Emergency, Day Treatment Unit - Pediatric Center - Vinmec Times City International Hospital.
Peptic ulcer in children is a fairly common disease, although not immediately life-threatening, in the long run, the disease, if not treated according to the right regimen, will cause serious complications. affect the health and development of children.
1. Using antibiotics to kill H.pylori
Some antibiotics have the effect of killing H.pylori bacteria including:
Amoxicillin: It prevents the synthesis and transport across the membrane of Mucopeptides by blocking Transpeptidase, leading to loss of bacterial wall. Metronidazole: Effective in reducing Hydroxylamine derivatives: Has effect on DNA damage of bacteria Tetrayclin: Attaches to RNAm in the 30s Ribosome part of HP -> RL protein synthesis of bacteria Clarythromycin: Acts on RNAt and part 50s of Ribosome -> bacterial protein synthesis RL
Vi khuẩn H.pylori là nguyên nhân gây bệnh viêm loét dạ dày tá tràng
2. Option 1 . regimen
Children with stomach ulcers can be treated according to the following regimen:
Amoxicillin + Clarithromycin + PPI (omeprazole) Amoxicillin + Metronidazole + PPI (omeprazole) Clarithromycin + Metronidazole + PPI (omeprazole) Dosage: Amoxicillin: Dosage: 50mg/kg /day up to 1g/day x 2 times/day Clarithromycin: Dosage 15mg/kg/day up to 500mg/day x 2 times/day PPI (omeprazole): Dosage 1 mg/kg/day, maximum 20mg x 2 times/day
3. Option 2 . regimen
In case the first choice regimen cannot be used to treat stomach ulcers in children, the following regimen can be used:
Bismuth subsalicylate (262mg x 4 times/day) + Metronidazole + PPI (omeprazole) 1 mg/kg/day up to 20mg x 2 times/day + one of the following drugs: Amoxicillin: Dosage 50mg/kg/day up to 1g/day x 2 times/day Tetracycline: Dosage 15 mg/kg/day max Maximum 500mg x 2 times/day Clarithromycin: Dosage 15mg/kg/day up to 500mg/day x 2 times/day Ranitidine bismuth citrate (1 tablet x 4 times/day) + Metronidazole + Clarithromycin
Có thể sử dụng amoxicillin theo phác đồ lựa chọn 2 điều trị viêm loét dạ dày cho trẻ
4. Evaluating the effectiveness of killing H.pylori
H.pylori eradication is defined as the complete eradication of bacteria as determined by one of the diagnostic methods with high reliability after the end of treatment ≥ 4-6 weeks, including:
Breathing test Histopathology Test rapid urease Bacterial culture Fecal antigen detection test (monoclonal antibody) When a child has been diagnosed with peptic ulcer disease, the family must strictly follow treatment regimens to prevent drug resistance.
Pediatrics department at Vinmec International General Hospital is the address for receiving and examining diseases that infants and young children are susceptible to: viral fever, bacterial fever, otitis media, pneumonia in With modern equipment, sterile space, minimizing the impact as well as the risk of disease spread. Along with that is the dedication from the doctors with professional experience with pediatric patients, making the examination no longer a concern of the parents.
Customers can directly go to Vinmec Health system nationwide to visit or contact the hotline here for support.
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Gastroduodenal ulcers in children: Diagnosis and treatment Do not be subjective with peptic ulcers in children Principles of treatment of peptic ulcers in children
