If left untreated, Von Hippel Lindau Syndrome can lead to blindness, brain damage, or even death. Death is usually due to complications from hemangiomas or renal cell carcinoma.

Classification and diagnosis of pancreatic cystic lesions is an important issue in planning further management. Endoscopic ultrasound and transcapillary diagnosis are the two main endoscopic methods used. EUS-guided fine needle aspiration (FNA) cytology and microneedle biopsy... are promising methods that have been used in differential diagnosis.