Hepatic veno-occlusive disease is caused by endothelial damage, resulting in non-thrombotic obstruction of the hepatic renal venules and hepatic sinuses rather than the hepatic vein or inferior vena cava (eg. in Budd-Chiari syndrome). The following article will clarify more about the dangers of hepatic vein occlusion or hepatic portal vein occlusion if it is not diagnosed and detected early.