Calcified fibrous tumors (CFTs) are rare benign mesenchymal tumors of the gastrointestinal tract. Originally thought to be tumors of soft tissue sites, recent studies have shown the gastrointestinal tract to be the primary site of these tumors. Calcified fibrous tumors present a diagnostic challenge due to overlapping histological features with multiple stromal lesions. Understanding the core clinical, histological and immunophenotypic features of calcified fibrosarcomas is important in making an accurate diagnosis.

The pathogenesis of calcified fibroblastomas remains unclear, but some have hypothesized that they may be involved in IgG4-related disease, inflammatory fibroblast injury, and vascular Castleman disease. hyalinemia, sclerotic nodular changes of the spleen, or trauma.