Savella or milnacipran is a selective serotonin and norepinephrine reuptake inhibitor (SNRI) and is indicated for the treatment of depression and muscle pain. The mechanism of action of milnacipran exhibits a somewhat unique feature compared with other SNRIs of inducing a relatively balanced reuptake inhibition of both serotonin and noradrenaline, thereby minimizing pain signals in these pathways. Inhibitory pain diminishes in the brain and spinal cord.

Antidepressants, including SSRIs and SNRIs, can help improve your symptoms of depression for a while. However, stopping these medications can lead to antidepressant discontinuation syndrome and other health problems. It is best to consult your doctor if you are considering stopping your medication.