Patients with inflammatory bowel disease (IBD) can develop complications from the disease itself and also from the immunosuppressive therapies used to treat it. To optimize care for patients with IBD, clinicians need to consider primary, secondary, and tertiary prevention. Primary prevention is used to prevent disease or complications from developing, such as vaccination. This review highlights prevention methods that can be used in patients with IBD through a partnership between the primary care provider and the gastroenterology department.