Allergic granulomatosis with polyangiitis (Churg-Strauss syndrome) is a multisystem disorder characterized by allergic rhinitis, asthma, and eosinophilia.

PPNI can result in sensory disturbances (loss of sensation, hypoesthesia, hyperesthesia, paresthesia, and pain in areas innervated by the affected nerves) and/or motor deficits (mild or even total paralysis of the affected muscles). Autonomic dysfunction and trophic changes can occur leading to severe neuropathic pain.