Abbreviation H. pylori-associated gastric cancer (HpPGC) Stomach cancer not caused by H. pylori infection ( Stomach cancer not caused by H. pylori infection ) Persistent Helicobacter pylori ( H. pylori ) infection causing chronic inflammation, atrophy of the gastric mucosa and a high risk of developing gastric cancer. In recent years, awareness of H.pylori eradication treatment has increased in Japan. As H. pylori infection decreases, the incidence of gastric cancer arising from gastric mucosa that is not infected with H. pylori increases. The occurrence of gastric cancer arising in patients without H. pylori infection, although rarely reported, is a concern that needs to be addressed and should elucidate the clinical features of this disease. it.