Thalassemia is a congenital hemolytic disease, inherited in a recessive gene pattern on the autosomal chromosome from parents to children through generations. The main manifestation of the disease is anemia with dangerous complications, affecting the race and ethnicity. Performing premarital tests is extremely necessary to accurately screen for Thalassemia genes, helping to determine whether couples carry the Thalassemia gene or not, thereby assessing the risk of Thalassemia in future children.