I am currently 20 weeks pregnant with twins. I have heterozygous alpha 3.7 deletion hemolytic anemia. Doctor, can you tell me if it is dangerous to have heterozygous alpha 3.7 deletion hemolytic anemia during pregnancy? My husband is probably normal because his blood formula is normal. I hope the doctor can advise me. Thank you.

HELLP syndrome in pregnant women is the most severe form of pregnancy poisoning that can threaten the lives of pregnant women and fetuses, often occurring in the late stages of pregnancy or after birth.

Blood transfusion is a condition in which a patient receives blood or blood products (red blood cells, platelets, plasma) from another person. This is a fairly common measure to compensate for lost blood or correct abnormalities in the blood when there is no other alternative. Blood transfusion is painless, it can be a little uncomfortable because the needle is attached to the vein of the arm, but there are still cases of dangerous complications that need to be handled promptly.

When the life span of red blood cells is shortened because the body produces autoantibodies against red blood cells, this is the main cause of autoimmune hemolytic disease. Red blood cells are destroyed by phagocytosis in the reticuloendothelial system or by activation of the complement system that causes red blood cell lysis.

Cold Agglutinin test is done to check for health conditions. Some infections, lymphoma, pneumonia cause the body to produce certain antibodies called cold agglutinins.

Abnormal antibodies are IgG in nature and often cause extravascular hemolysis. Abnormal antibodies can also cause acute hemolysis if the patient has a secondary immune response (mother-child incompatibility).