Hepatocellular carcinoma (HCC) is a malignancy that often occurs in the background of chronic liver disease and cirrhosis. The disease is often diagnosed late and has a poor prognosis and is difficult to treat.

Liver cancer is the most common cancer, ranking 5th in men and 7th in women. Early detection is highly effective in treatment. Ultrasound and Tumor markers recommended for screening for early detection of liver cancer are now available, including AFP, PIVKAII (DCP) and AFP-L3. The following article summarizes the meaning and usage of these tests.