Exocrine pancreatic insufficiency is a malabsorption condition that occurs when the pancreas fails to produce important digestive enzymes. If the exocrine function of the pancreas fails to produce these enzymes, the body will not be able to digest food and absorb nutrients, especially fats. Accordingly, people with exocrine pancreatic insufficiency will not be able to digest food properly or often experience indigestion due to malabsorption.