Noonan syndrome with multiple moles is an autosomal dominant inherited RAS disease. The incidence of this rare disease is unknown.

The most common neurocutaneous disorders encountered in neurology clinical practice include NF1, Legius syndrome, neurofibromatosis type 2 (NF2), Noonan syndrome with multiple nevi, tuberous sclerosis... Most neurocutaneous syndromes are classified as monogenic disorders. However, they have autosomal dominant, autosomal recessive, or X-linked inheritance patterns.