Factor VIII is a normal protein found in the blood that helps the blood to clot. In people with low factor VIII (hemophilia A), there is a higher risk of prolonged bleeding or non-clotting, making the patient need help with Kogenate FS.

Factor IX is a protein found in the blood that helps the blood to clot, thus helping to stop bleeding in the event of an injury or accident. In people with low factor IX (with hemophilia B), there is a higher risk of prolonged bleeding or non-clotting, making the patient needing Ixinity for treatment.