Kogenate FS: Uses, indications and notes when using

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Factor VIII is a normal protein found in the blood that helps the blood to clot. In people with low factor VIII (hemophilia A), there is a higher risk of prolonged bleeding or non-clotting, making the patient need help with Kogenate FS.

1. Designation

Kogenate FS is used to control and prevent bleeding episodes in people with low factor VIII (Hemophilia A ), who are also at increased risk of bleeding for longer after trauma/surgery and bleeding. blood in the body (especially in joints and muscles). Kogenate FS is also used in these patients before surgery to prevent these risk factors.
Kogenate FS contains a man-made form of factor VIII, also known as Anticoagulant Factor (AHF). This medication is used to temporarily replace missing factor VIII, so that the blood can clot and stop bleeding.
Note: Kogenate FS is not used to treat von Willebrand disease.

2. Dosage and usage

Kogenate FS is usually given intravenously as directed by your doctor. The drug may be given slowly over a longer period depending on your dose or response to it. After the first infusion of this medication at a medical center or hospital, some patients are able to self-administer Kogenate FS at home. If your doctor has given you permission to use this medication at home, read the instructions for use in the product packaging and packaging carefully before infusing the medication. If Kogenate FS and the reconstituted solution are both stored in the refrigerator, allow both to come to room temperature before reconstituting the infusion mixture. After mixing the solution into the powder, gently swirl the mixture (do not shake) so that the powder is completely dissolved. Before infusing this medication, visually inspect it for particles or signs of discoloration. If so, stop using the liquid. Dosage is based on your medical condition, weight, blood test results, and response to treatment. Follow the dose as directed by your doctor.

3. Undesirable effects

Similar to many other infusion drugs, Kogenate FS can also bring some side effects such as:
Facial flushing, headache, nausea and heart palpitations during infusion (which can be alleviated by giving slower infusion). Signs of burning, redness, swelling, irritation at the injection site, fever and chills. If any of these effects persist or tend to get worse, tell your doctor right away.
Allergies to Kogenate FS are also rare. However, if you see signs of a serious allergic reaction such as: severe dizziness, rash, itching and swelling of the face, tongue, throat, difficulty breathing, etc., seek medical help as soon as possible. good.

4. Caution

Before taking Kogenate FS, be aware of the following:
If you are allergic to any product with clotting factor (factor VIII) or any other allergic condition, please immediately notify the doctor; Some brands of medicine may also contain polyethylene glycol (PEG), or inactive ingredients (such as natural rubber, latex) that can cause allergic reactions or other problems. Talk to your doctor for more details. For pregnant women, Kogenate FS should only be used when absolutely necessary. Discuss the risks and benefits of the medication with your doctor. It is not known whether Kogenate FS passes into breast milk. Therefore, consult your doctor before breast-feeding.

5. Some notes

Overdose: If you overdose on Kogenate FS and experience symptoms such as fainting or difficulty breathing, take the patient to the emergency room immediately. Patients are encouraged to have regular physical exams, including a blood factor VIII test...to determine the dose and check how well this medicine is working. Missed dose: If 1 dose is missed. medication, it should be given as soon as you remember. If it is almost time for the next dose, skip the missed dose. Do not double the dose. Storage: Store Kogenate FS according to the manufacturer's instructions. Do not freeze the medicine or store it in a bathroom or well-lit place. After mixing, use the mixture within the time frame stated in the manufacturer's instructions and discard the unused portion. Do not leave this medicine within the reach of children and pets.

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Reference source: Webmd