Occurrence of bile reflux is often associated with disturbances in the functioning of the pyloric valve and the esophageal sphincter. Symptoms of bile reflux are similar to those of gastroesophageal reflux such as upper abdominal pain, heartburn, vomiting, and nausea.

Bile reflux is difficult to distinguish from acid reflux, requiring additional tests to confirm. The disease is treated with drugs and surgery in cases where there is a risk of cancer progression.

Bile is secreted in hepatocytes and then enters the bile ducts into the second part of the duodenum (below the stomach) and participates in the digestion of food, especially the digestion of fats. Every day the body secretes about 600ml - 1 liter of bile.