The article was written by MSc. Dr. Le Thi Na - Hematologist, Laboratory Department - Vinmec Times City International General Hospital. Abnormal antibodies are IgG in nature, often causing extravascular hemolysis. Abnormal antibodies can also cause acute hemolysis if the patient has a secondary immune response (incompatibility between mother and child).

Screening for abnormal antibodies is performed to reduce the risk of transfusion and post-transfusion complications in patients. The test is also performed on pregnant women whose blood group is Rh incompatible with that of the fetus.