Cause of the disease is not clear, the pathogenic mechanism is believed to be rupture of membranes in early pregnancy leading to the development of many amniotic bands from the chorion side of the amniotic membrane entangled into the embryo or germ disc.

Amniotic band syndrome is a rare condition in which bands of amniotic sac membrane separate and become entangled with the baby’s fingers, toes, or other parts of the body. This constriction can cause a variety of complications, depending on the location of the amniotic bands and how tightly they are wrapped. However, in some cases, babies are born with functional disabilities in parts of their bodies.