Liver cancer screening to detect early signs of the disease is highly recommended, especially for those at high risk of developing liver cancer. One of the important tests that contributes to screening and early diagnosis of liver cancer is the AFP (Alpha-Fetoprotein) test.

Worldwide, hepatocellular carcinoma is the third leading cause of cancer death. The incidence of hepatocellular carcinoma in the United States has doubled over the past 25 years, largely due to the increasing prevalence of hepatitis C virus infection. When diagnosed early, hepatocellular carcinoma can be cured with liver transplantation or surgical resection.