Before the 2019 COVID pandemic, humanity had experienced the 2003 SARS pandemic with similar characteristics. Understanding SARS provides a lot of experience for the prevention of respiratory diseases in general. So how did the SARS virus that caused the 2003 pandemic spread? This is a question that many people want to know at the present time.

The complicated developments of the COVID-19 pandemic have caused scientists and the community to search for information about the global SARS epidemic in 2003. Valuable lessons learned in the fight against the SARS epidemic in 2003 are valuable experiences for both the world and Vietnam in the fight against the COVID-19 epidemic caused by the new coronavirus strain 2019.

Existing evidence demonstrates that liver injury in SARS-CoV-2 infection is the result of a multifactorial attack. Potential pathogenetic mechanisms may be broad, ranging from direct cytotoxicity due to viral infection to indirect involvement of inflammatory cytokine storm, hypoxic alterations due to respiratory failure, endothelial inflammation, and drug-induced liver injury (DILI).