Xatral XL side effects

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Xatral XL is used in the symptomatic and functional treatment of benign prostatic hypertrophy, in addition, the drug is used in adjuvant treatment in case of acute urinary retention requiring catheterization due to benign prostatic hypertrophy.

1. What is Xatral XL?

What is Xatral XL? Xatral XL brand-name drug has the main ingredient Alfuzosin hydrochloride with a strength of 10mg. How much does Xatral XL 10mg cost? Xatral XL 10mg drug has a declared price of 16,056 VND/tablet, packed in a box with 3 blisters, each blister contains 10 tablets.
Alfuzosin is a Quinazolin derivative with selective postsynaptic antagonistic effects on alpha1 - adrenergic receptors. Alfuzosin is selective for alpha1-adrenergic receptors in the lower urinary tract, prostate, fundus, bladder neck, and urethra. Alfuzosin acts directly on the smooth muscle of the prostate, relieving obstruction in the bladder neck and pressure in the urethra, thereby reducing urinary obstruction.
In a placebo-controlled study in patients with benign prostatic hypertrophy, Alfuzosin had the following effects:
In patients with urine output less than 15 mL/s, Alfuzosin significantly increased flow about 30% and this effect usually appears after the first dose. Significantly reduces the contractile pressure of the bladder sphincter. Also increases urine volume, thus restoring the urge to urinate. Significant reduction in the volume of urine remaining in the bladder after urination. These effects help improve symptoms of urinary irritation and obstruction.

2. Indications and contraindications for taking Xatral XL

2.1. Point

Symptomatic and functional treatment of benign prostatic hypertrophy. Adjuvant therapy in acute urinary retention requiring catheterization due to benign prostatic hypertrophy.

2.2. Contraindications

Allergy or hypersensitivity to Alfuzosin or any of the excipients. Postural hypotension. Severe liver failure. Severe renal impairment (creatinine clearance <30ml/min). Contraindicated in combination with alpha-blocker antihypertensive drugs, cytochrome P450 inhibitors, CYP3A4 isoenzymes such as Ritonavir, Ketoconazole, Itraconazole.

3. How to take Xatral XL

Xatral XL 10mg is taken orally, after dinner. Must take the whole pill; Do not bite, chew, or crush Xatral XL tablets.
In the case of catheterization to prevent acute urinary retention, the drug should be administered from the first day of intubation and administered for 3 to 4 days, that is, during the 2 to 3 days of catheterization and after extubation for 1 day. Dosage of Xatral XL in this case: 1 tablet/day.
While taking Xatral XL 10mg extended-release tablets, if you feel the effects of the drug are too strong or too weak, you should notify your doctor to adjust the dose appropriately.
Dosage of Xatral XL: 1 tablet/day.

4. Xatral XL drug overdose and treatment

A possible symptom of an overdose of Xatral XL is severe hypotension.
Management: If the patient has recently used Xatral XL within 1 hour, activated charcoal can be given to the patient. Applying measures to lower blood pressure such as lying with the head low, giving fluids to replenish the circulating volume. In severe cases, vasopressors may be prescribed.
Alfuzosin cannot be removed by hemodialysis due to its high protein binding capacity.

5. Side effects of Xatral XL

Side effects of the drug Xatral XL
Digestive disorders, common: Abdominal pain, nausea, diarrhea, dry mouth Nervous: Fainting, dizziness, dizziness, lightheadedness, irritability, headache. Body as a whole: Fatigue, weakness. Cardiovascular: Postural hypotension, increased heart rate, palpitations, flushing, edema. Angina may be experienced in patients with a history of coronary artery disease. Respiratory: Nasal congestion, bronchitis, sinusitis, pharyngitis and upper respiratory tract infection. Skin: Skin allergies, itching, urticaria are uncommon. Some other possible effects (but frequency is not determined): Hepatocellular damage, cholestatic hepatitis, jaundice; Genitourinary - urogenital: Prolonged penile pain, impotence. Side effects of Xatral XL such as weakness, dizziness, dizziness, headache, nausea, palpitations may disappear with continued treatment or dose reduction.
To reduce the risk of fainting or fainting after taking the first dose, Xatral XL should be taken at night before bedtime. In particular, the first dose should be reduced when used in the elderly.

6. Some notes when using Xatral XL

Symptoms of prostate cancer are often similar to those of benign prostatic hypertrophy, so cancer must be ruled out before starting Xatral XL 10mg.
Patients with particular sensitivity to Xatral XL may present with orthostatic hypotension with or without symptoms (fatigue, dizziness, sweating). This symptom appears within a few hours of taking the first dose and may lead to fainting. Particular caution should be exercised in patients with symptomatic hypotension or hypotension when taking other medicinal products.
If this occurs, place the patient in a low lying position until these temporary symptoms completely disappear. However, this low blood pressure usually passes quickly and does not necessarily necessitate discontinuation of treatment
Intraoperative floppy iris syndrome (IFIS) has been observed in some patients taking or previously taking this medication. alpha blockers during cataract surgery. If you are planning to have cataract surgery in the near future and are taking or have been taking Xatral XL 10mg, please inform your doctor so that you can choose the right surgical method.
Xatral XL 10mg should be used with caution in the elderly, with a history of liver or kidney disease, and in patients with marked hypotension when taking other alpha blockers.
Patients with coronary artery disease, Xatral XL should not be used alone. Continue specific treatment of coronary insufficiency for the patient. In case of worsening or recurrent angina, Xatral XL should be discontinued.
Must take the entire Xatral XL pill. Do not bite or crush the tablet into a powder. This will lead to inappropriate drug release and absorption leading to undesirable effects that may have an earlier onset.
Ability to drive and use machines: Alert the operator to the risk of orthostatic hypotension, fatigue, feeling dizzy or visual disturbances, especially at the start of treatment.
Pregnant women: The safety of Alfuzosin in pregnant women has not been established. Xatral XL should not be used by pregnant women.
Lactating women: Xatral XL should not be used in nursing mothers because it is not known whether Alfuzosin is excreted in human milk.

7. Drug interactions

Antihypertensive drugs of the alpha receptor block (prazosin, trimazosin, urapidil): Concomitant use with Xatral XL increases the antihypertensive effect, the risk of exacerbation of orthostatic hypotension. In addition, caution should be exercised when used with other antihypertensive agents because of the increased risk of excessive hypotension.
Drugs that inhibit the activity of cytochrome P450, isoenzyme CYP3A4 such as Ketoconazole, Ritonavir, Itraconazole can increase the concentration of Alfuzosin in the blood and increase unwanted effects.
Phosphodiesterase type 5 inhibitors (Tadalafil, Sildenafil, Vardenafil) increase the risk of orthostatic hypotension, especially in the elderly.
Nitrates, nitrites and related drugs when used concurrently with Xatral XL increase the risk of hypotension, especially orthostatic hypotension.
Atenolol, Diltiazem when co-administered with Alfuzosin increased plasma concentrations of both drugs.

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