This is an automatically translated article.
The article was written by BS. Tran Thi Huyen Trang, Laboratory Department, Vinmec Times City International General HospitalThe SGOT test is an important test in identifying liver disease and monitoring its progression. This test also helps to determine the state of cell destruction, especially of liver, cardiac, and skeletal muscle origin. When red blood cells are broken, SGOT is very high, what is the mechanism of this phenomenon?
1. What is AST (SGOT)?
AST (Aspartate aminotransferase) and ALT (Alanin aminotransferas) belong to the group of enzymes that catalyze the conversion of amino acids into α-ketonic acids and vice versa. ASTs are present in the cytoplasm as well as in mitochondria and are found mainly in cells of the heart, liver, skeletal muscle, kidney, pancreas, red blood cells, platelets, etc. AST is released into the circulation when it occurs. damage or death of cells containing this enzyme.
The AST test is a useful test in identifying a liver disease and monitoring its progression. It is one of the most sensitive tests for detecting viral and drug-induced hepatocellular damage (increased liver enzyme activity may precede weekly hyperbilirubinemia). In addition, AST test is also indicated in cardiovascular disease to evaluate myocardial infarction, myocarditis (when combined with ALT, CK - MB mass and Troponin T/I).
2. In what cases is the AST test indicated?
The test helps to determine whether the cellular breakdown is due to liver, cardiac or skeletal muscle origin. Therefore, the AST activity test is usually indicated in the following cases:Weakness, feeling of loss of energy, fatigue; Weight loss, jaundice, yellow eyes;
Người bệnh xuất hiện triệu chứng vàng da vàng mắt được chỉ định xét nghiệm AST
Ascites; Nausea, vomiting, diarrhea, loss of appetite; Change in color of discharge (such as dark urine, pale stools); Abdominal pain, unusual bleeding; Itchy ; Swelling in the legs and ankles; Bruises; Chest pain; Muscle pain; Some other reasons:
Exposure to hepatitis virus; Drinking a lot of alcoholic beverages; Taking drugs that can cause liver damage; Fat; Diabetes or metabolic syndrome.
3. Why is SGOT so high when red blood cells burst?
RBC rupture (hemolysis) is defined as the release of red blood cell contents into the plasma. The release of hemoglobin causes serum or plasma to appear pale red to cherry red.
RBC rupture in the body is the result of immunological, biochemical, physiological or chemical mechanisms. RBC rupture can be intravascular and extravascular. Intravascular hemolysis is rare and usually results from a transfusion reaction or hemolytic anemia. Extravascular hemolysis is quite common and occurs during improper venipuncture, handling, transport, and storage techniques that cause pre-examination errors.
Kỹ thuật lấy máu tĩnh mạch không đúng gây ra huyết tán ngoại mạch
Release of components of blood cells into plasma or serum. Some cellular components are present in concentrations up to 10 times higher in the cell than extracellularly, and serum/plasma hemolysis leads to increased concentrations of these components. Here the AST present in the red blood cells is released into the blood. Spectrophotometric/colorimetric interference by hemoglobin (changing serum/plasma color interferes with assay technique). For AST testing, you should go to reputable medical facilities with modern equipment to get the most accurate results.
Vinmec International General Hospital is a high-quality medical facility in Vietnam with a team of highly qualified medical professionals, well-trained, domestic and foreign, and experienced.
A system of modern and advanced medical equipment, possessing many of the best machines in the world, helping to detect many difficult and dangerous diseases in a short time, supporting the diagnosis and treatment of doctors the most effective. The hospital space is designed according to 5-star hotel standards, giving patients comfort, friendliness and peace of mind.
Please dial HOTLINE for more information or register for an appointment HERE. Download MyVinmec app to make appointments faster and to manage your bookings easily.
