What is Tatanol Ultra?

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Tatanol ultra is often used in some cases of musculoskeletal pain, headache, back pain, arthritis,... So what is Tatanol ultra and how is it safe and effective to use?

1. What is Tatanol ultra?


Tatanol ultra is made in the form of tablets, this is an analgesic and antipyretic, containing the main active ingredient in each tablet:
Acetaminophen 325mg; Tramadol 37.5mg Acetaminophen is more commonly known as Paracetamol. This is the active metabolite of Phenacetin, which is an effective analgesic - antipyretic that can replace Aspirin.
Acetaminophen has the effect of lowering body temperature in febrile patients, but rarely causes hypothermia in normal people. This active ingredient acts on the hypothalamus to cause hypothermia, increased heat loss due to vasodilation and increased peripheral blood flow.
With therapeutic doses, Acetaminophen has little impact on the cardiovascular and respiratory systems, the drug does not change the acid - base balance, does not cause irritation, ulcers or stomach bleeding like when using Salicylates.
Tramadol hydrochloride is an effective analgesic, belonging to the group of central analgesics. It has analgesic effects comparable to narcotic analgesics but does not cause respiratory depression like narcotic analgesics.

2. Indications and contraindications of Tatanol ultra


Tatanol ultra is used to relieve pain and reduce fever in the following conditions:
Headaches including migraine and tension headaches; Musculoskeletal pain; Arthritis, the drug is effective in reducing pain in mild arthritis but has no effect on inflammation and swelling deep in the joint; Backache; Toothache; Colds, flu; Dysmenorrhea ; Sore throat. Tatanol ultra is contraindicated in the following cases:
People with hypersensitivity to Acetaminophen, Tramadol or any other ingredients of the drug; a history of hypersensitivity to other opiate-like drugs; Acute poisoning with other central nervous system depressants (such as alcohol, other central analgesics, tranquilizers, hypnotics, other opiate-like drugs, psychotropic drugs); Severe respiratory depression; Severe kidney or liver failure; Uncontrolled seizures; Concurrent treatment or recently stopped treatment with a monoamine oxidase inhibitor within 15 days; Children under 12 years old. Use caution when using Tatanol ultra in the following cases:
Pregnant women: Because Tramadol crosses the placenta, the use of the drug during pregnancy has caused some cases of seizures and syndromes. smoking cessation in newborn, fetal or infant death. Therefore, Tatanol ultra should only be used during pregnancy if the potential benefit outweighs the risk to the fetus. Do not use Tatanol ultra before and during parturition. Women who are breast-feeding because the safety of the drug in infants and young children has not been studied.

3. Dosage and how to use Tatanol ultra


Tatanol ultra is used orally, can be taken on an empty or full stomach.
Adults and children over 12 years: Use a maximum dose of 1 to 2 tablets every 4 to 6 hours and not more than 8 tablets in 1 day; Children under 12 years of age: The safety and effectiveness of Tatanol ultra have not been studied in children; Elderly (over 65 years): No differences in safety or pharmacokinetic properties were observed between users over 65 years of age and younger subjects. The clinical manifestations of an overdose of Tatanol ultra can be signs or symptoms of Tramadol, Paracetamol poisoning or both:
Tramadol: Tramadol overdose can cause respiratory depression, coma coma, convulsions, cardiac arrest and death; Paracetamol: Using high doses of Paracetamol can cause liver toxicity. Early symptoms that may appear after liver damage due to Paracetamol overdose include: Gastrointestinal irritation, loss of appetite, nausea, vomiting, paleness, sweating, irritability. Symptoms of hepatotoxicity may appear 48 - 72 hours after taking the drug. 4. Side effects of Tatanol ultra The most frequent side effects when using Tatanol ultra are on the central nervous system and digestive system. The most common symptoms are nausea, dizziness, drowsiness.
Some of the following side effects also occur when using Tatanol ultra , but less often :
Body as a whole: Asthenia , fatigue , strong emotions ; Nervous system: Headache, shivering; Digestive system: Abdominal pain, indigestion, flatulence, dry mouth, vomiting, constipation, diarrhea; Psychiatric disorders: Anxiety, confusion, agitation, insomnia, restlessness, loss of appetite; Skin: Itching, rash, increased sweating. Reports of rare clinical adverse events possibly related to Tatanol ultra include:
Systemic: Chest pain, chills, syncope, withdrawal syndrome; Cardiovascular system: Hypertension, severe hypertension, hypotension, arrhythmia, palpitations, tachycardia; Nervous system: Loss of balance, convulsions, muscle tension, involuntary muscle contractions, migraine, severe migraine, paresthesia, stupor, dizziness; Digestive system: Difficulty swallowing, black stools due to gastrointestinal bleeding, tongue edema; Ears: Tinnitus; Liver and bile: Abnormal liver tests; Metabolic and nutritional disorders: Weight loss; Psychiatric Disorders: Amnesia, loss of consciousness, substance abuse, depression, mood swings, hallucinations, nightmares, impotence, abnormal ideas; Blood: Anemia ; Respiratory system: Shortness of breath; Urinary system: Urinary disorders, little urine, urinary retention, Albuminuria; Vision: Abnormal vision. Other side effects of Tramadol hydrochloride in Tatanol ultra were observed before clinical trials and post-marketing:
Orthostatic hypertension; Allergic reactions including anaphylaxis, urticaria, Stevens-Johnson syndrome; Cognitive dysfunction, suicidal ideation; Hepatitis ; Creatinine increased; Serotonin syndrome occurs when tramadol is administered with serotonin-acting agents such as selective serotonin reuptake inhibitors and MAO inhibitors. 5. Interactions of Tatanol ultra with other drugs Concomitant use of Tatanol ultra with MAO inhibitors or Serotonin reuptake inhibitors may increase the risk of side effects, including seizures and Serotonin syndrome ; Concomitant use of Tatanol ultra with carbamazepine significantly increases the metabolism of Tramadol, reducing the effect of the drug; Taking quinidine with Tatanol ultra will increase the level of Tramadol in the blood; The use of Tatanol ultra with drugs of the Warfarin class may increase the INR (international normalized ratio) in some patients; Studies have shown that the use of Tatanol ultra together with CYP2D6 inhibitors such as Fluoxetine, Paroxetine and Amitriptyline may limit the metabolism of Tramadol. The above are the uses and notes when using Tatanol ultra. This is a pain reliever and fever reducer. Any drug can have adverse effects on the body, so use it only when needed.

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