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Rostor 10mg product is a drug that is only sold when prescribed by a doctor. Patients are not allowed to buy and use the drug on their own due to the risk of serious side effects. So what is Rostor 10mg?
1. What is Rostor 10mg?
The composition of each Rostor 10mg film-coated tablet contains the main active ingredient, Rosuvastatin 10mg, and the excipient system includes: Anhydrous lactose, microcrystalline cellulose, calcium hydrophosphate, magnesium stearate, PVP K30, hypromellose, glycerol triacetate, titanium dioxide . Rosuvastatin is a selective and competitive inhibitor of HMG-CoA reductase. This is the enzyme responsible for catalyzing the conversion of 3-hydroxy-3-methylglutaryl coenzyme A to mevalonate (a precursor of cholesterol). The main site of action of rosuvastatin is the liver, which lowers cholesterol, increases the number of LDL receptors on the surface of hepatocytes, increases the absorption and catabolism of LDL, inhibits the synthesis of VLDL in the liver, the end result is reduces VLDL and LDL components.2. Indications of the drug Rostor 10mg
Rostor 10mg is indicated in cases of primary hypercholesterolemia (type lla, including heterozygous familial hypercholesterolemia); Mixed dyslipidemia (class lIb): Rostor 10mg is an adjunct to diet when patients have not responded adequately to diet and other non-pharmacological (collective) therapies. education, weight loss); Rostor 10mg for the treatment of homozygous familial hypercholesterolemia: adjunct to diet and other lipid-lowering treatments (LDL extraction) or indicated when these therapies are not appropriate. fit.
3. Dosage of the drug Rostor 10mg
Before starting treatment with Rostor 10mg, patients must follow a standard diet with the aim of lowering cholesterol and continue to maintain this diet for the duration of treatment with Rostor 10mg.
The recommended starting dose of Rostor 10mg is 5mg or 10mg, once a day. The starting dose of Rostor 10mg depends on the current cholesterol level of the individual patient, the cardiovascular risk of this and the possibility of unwanted side effects when using Rostor 10mg. The dose of Rostor 10mg can be adjusted every 4 weeks if needed.
Doses of Rostor 10 mg up to 40 mg should only be considered in patients with severe hypercholesterolemia at high risk for cardiovascular disease (particularly familial hypercholesterolemia) but who are not meeting the therapeutic target at 20 mg. When using this dose, the patient should be monitored regularly.
Elderly: Rostor 10mg should be used with a starting dose of 5mg/day. Patients with renal failure with creatinine clearance 30-60 ml/min: The initial dose should be 5mg/time/day and the maximum dose is 20mg/day. Patients with renal failure with creatinine clearance <30ml/min: Contraindicated using Rostor 10mg. Children: The safety and effectiveness of Rostor 10mg have not been established. Treatment of Rostor 10mg in combination with other drugs:
Limit the maximum dose of Rosuvastatin to 10mg/time/day when co-administered with Atazanavir, the combination form of Atazanavir and Ritonavir, the combination form of Lopinavir and Ritonavir.
4. Contraindications of the drug Rostor 10mg
Hypersensitivity to the ingredients of the drug Rostor 10mg. Progressive liver disease, persistent elevation of serum transaminases, unexplained, serum transaminase levels more than 3 times the upper limit of normal. Severe renal impairment (with creatinine clearance < 30 ml/min). Muscular diseases; Using cyclosporin. Pregnant and lactating women should not use Rostor 10mg.
5. Notes when using Rostor 10mg
In order to use the drug safely, patients need to pay attention to the following:
Reduce dose of Rostor 10mg in patients with renal failure and monitor kidney function when treating with 40mg dose; Use caution when administering Rostor 10mg to elderly patients. Rosuvastatin should not be used in patients with serious acute conditions, suspected myopathy, or possible renal failure secondary to rhabdomyolysis (patients with active sepsis, hypotension, major surgery, trauma, disorders, etc.) electrolyte disturbances, severe endocrine and metabolic disorders, uncontrolled convulsions). Liver enzyme tests before starting treatment with Rostor 10mg; Consider creatine kinase (CK) monitoring in the following cases: Before receiving Rostor 10mg, a CK test should be performed in the presence of impaired renal function, hypothyroidism, history of hereditary myopathy, history of history of myopathy due to statin or fibrate use, history of liver disease and/or heavy alcohol consumption, and patients >70 years of age with risk factors for rhabdomyolysis. In these cases, the benefit/risk ratio of Rosuvastatin should be weighed and the patient monitored clinically during statin therapy. If the CK test result is >5 times the upper limit of the reference range, the patient should not be treated. Initiate statin therapy in the patient. During the course of treatment with Rostor 10mg, patients need to notify their doctor as soon as they have muscle symptoms such as muscle pain, stiffness, muscle weakness..., need to do a CK test for intervention measures. Fit.
6. Side effects of the drug Rostor 10mg
Undesirable effects of the drug Rostor 10mg are common: headache, dizziness, nausea, abdominal pain, myalgia, asthenia, hypersensitivity (rarely including angioedema), rhabdomyolysis, arthralgia, increased liver enzymes, polyneuropathy, cognitive impairment, hyperglycemia, elevated HbA1C.
7. Interaction of Rostor 10mg with other drugs
Rostor 10mg drug interacts with vitamin K antagonists (warfarin): increases INR values when used concurrently; Increased risk of muscle damage when using Rostor 10mg drug concurrently with drugs: Gemfibrozil, fibrate drugs, high dose niacin (>1g/day), colchicine; Antacids: Concomitant administration of Rostor 10mg with a suspension of antacids containing aluminum and magnesium reduces plasma concentrations of rosuvastatin by approximately 50%; Erythromycin: Co-administration of Rostor 10mg with Erythromycin will reduce the AUC and Cmax of rosuvastatin by about 20% and 30% because Erythromycin increases intestinal motility; Birth control pills or hormone replacement therapy: Rostor 10mg will increase Ethinyl Estradiol AUC by 26% and Norgestrel AUC by 34% when taken together; Concomitant use of Rostor 10mg with HIV and hepatitis C virus (HCV) protease inhibitors may increase the risk of muscle damage, rhabdomyolysis, kidney failure leading to kidney failure, even death .
8. Overdose of Rostor 10mg
There is currently no specific treatment for an overdose of Rostor 10mg. In case of overdose, the patient will treat symptomatically and apply supportive measures when necessary: monitor liver function and CK levels.
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