This is an automatically translated article.
Vastanic 10 is indicated in the treatment of hypercholesterolemia and primary prevention of coronary events. Since the synthesis of cholesterol in the liver occurs mainly at night, taking Vasanic with the evening meal will increase the potency of the drug.
1. What is Vastanic?
Vastanic belongs to the group of cardiovascular drugs, containing the main active ingredient is Lovastatin and excipients just enough. Packing specification box of 3 blisters, 10 blisters x 10 film-coated tablets and box of 1 bottle x 100 film-coated tablets.
This is a prescription drug, so patients are not allowed to use it without a doctor's prescription.
2. Uses of Vastanic 10
Vastanic medicine 10 mg is used in the treatment of the following diseases:
Treatment of hypercholesterolemia: Vastanic is indicated as an adjunct to dietary therapy to reduce total cholesterol and LDL cholesterol in patients with elevated blood cholesterol. primary blood cholesterol (types IIa and IIb). Primary prevention (level 1) in patients with coronary events: In people with hypercholesterolemia but no clinical manifestations of coronary artery disease, the use of Vastanic is indicated to reduce the risk of myocardial infarction, coronary revascularization procedures, unstable angina, and secondary prevention of coronary events. Treatment of atherosclerosis: This is one of the uses of Vastanic 10 mg. In patients with hypercholesterolemia with clinical manifestations of coronary artery disease, including prior myocardial infarction, Vastanic is indicated to slow the progression of coronary atherosclerosis and reduce the risk of acute coronary events.
3. Dosage and how to use Vastanic 10 mg
How to take Vastanic:
Vastanic is taken orally; Patients need to follow a standard, low-cholesterol diet before taking Vastanic and continue to maintain this diet throughout the course of treatment; Adjust dosage according to individual patient needs and response by increasing doses at intervals of not less than 4 weeks, until safe LDL cholesterol levels or maximum dose are reached; The synthesis of cholesterol in the liver occurs mainly at night, so taking Vasanic with the evening meal will increase the effectiveness of the drug. Dosage of Vastanic 10 mg:
The starting dose of Vastanic is 20 mg and the daily maintenance dose is 20-80 mg; Do not use more than 20 mg Lovastatin/day when used concomitantly with the drugs Danazol, Diltiazem and Verapamil; Do not exceed 40 mg Lovastatin/day when used with Amiodarone; For patients with heterozygous familial hypercholesterolemia 10-17 years of age, the recommended dose range is 10-40 mg/day; The maximum dose is 40 mg/day. Vastanic is effective when used in combination with bile acid sequestrants. Patients with severe renal impairment (with creatinine clearance <30 ml/min) should avoid increasing the dose to more than 20 mg/day.
4. Contraindications when using Vastanic 10
Do not use Vastanic in the following cases:
People with signs of hypersensitivity to any ingredient of the drug. Active liver disease or unexplained persistent elevations in serum transaminases; Pregnant and lactating women should not use Vastanic drugs; Contraindicated using Vastanic in combination with CYP 3A4 inhibitors such as Itraconazole, Posaconazole, Erythromycin, Ketoconazole, Clarithromycin and Telithromycin; HIV protease inhibitors such as Telaprevir, Boceprevir or Nefazodon; Avoid concurrent use of Vastanic with Cyclosporin, Gemfibrozil; Avoid using large amounts of grapefruit juice (>1 liter/day) while using Vastanic 10; Do not exceed 20mg Vastanic/day when used concomitantly with Danazol, Diltiazem or Verapamil; Do not exceed 40mg Vastanic/day when used with Aamiodaron; Do not use Vastanic in combination with drugs containing Cobicistat.
5. Undesirable effects when using Vastanic
Vastanic is well tolerated, with a lower discontinuation rate compared to other lipid-lowering agents.
Common side effects when using Vastanic drugs:
On the digestive system: The drug causes diarrhea, constipation, flatulence, abdominal pain, nausea and vomiting; Central nervous system: Patients have symptoms of headache, blurred vision, dizziness, insomnia, body weakness; Neuromuscular and skeletal: Musculoskeletal pain; Liver: The increase in liver enzymes is reversible upon discontinuation of Vastanic. Rare side effects when using Vastanic:
Nerve - muscle and bone: Myopathy; Skin: Rash on the skin; Respiratory: Nasopharyngitis, sinusitis, cough. Rare side effects when using Vastanic:
Neuromuscular and skeletal: Rhabdomyolysis, secondary acute renal failure; Cognitive impairment such as confusion, memory loss; Hyperglycemia and increased HbAlc. Inform your doctor immediately of the unwanted effects that you experience when using Vastanic for appropriate management.
6. Vastanic 10 . drug interactions
Lovastatin may increase the effects of Warfarin; Bile acid-binding resins can markedly reduce the bioavailability of Vastanic when co-administered. Therefore, these two drugs must be taken at a distance from each other. Vastanic in combination with drugs Itraconazole, Ketoconazole, Boceprevir, Telaprevir, Posaconazole, Voriconazole, Macrolide antibiotics, Telithromycin antibiotics, HIV Protease inhibitors, Nefazodon or drugs containing Cobicistat will increase the plasma concentration of Lovastatin and make increased risk of myopathy. When Vastanic is used concurrently with Gemfibrozil, other Fibrate-lowering agents, high-dose Niacin and Colchicin, there will be an increased risk of muscle damage; Vastanic taken with medicines for HIV and hepatitis C can increase the risk of muscle damage, more serious rhabdomyolysis, kidney failure, and death. Vastanic in combination with Cyclosporin, Colchicin, Amiodarone, Ranolazine increases the risk of rhabdomyolysis; Co-administration of Vastanic 10 mg with Danazol, Diltiazem, Verapamil increases the risk of rhabdomyolysis; When Vastanic is used together with fusidic acid, the patient should be closely monitored because the risk of myopathy may be increased.
7. Treatment of forgetting or overdose of Vastanic
In case you miss a dose, take it as soon as you remember. However, if it is almost time for the next dose, skip the missed dose. Do not take a double dose of Vastanic to make up for a missed dose.
When taking an overdose of Vastanic, you need to notify your doctor immediately for appropriate treatment. If you see any abnormality after taking an overdose, you need to go to the hospital for timely treatment.
Vastanic medicine should be stored in a cool, dry place, the temperature is below 30 degrees Celsius. Avoid direct sunlight on the medicine and keep it out of reach of children.
Above is information about the uses, dosage and usage of Vastanic 10 mg medicine. All information in this article is for reference only. The use of the drug must follow the instructions of a professional doctor to ensure safety for health.
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