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Protomac 40 belongs to a class of selective proton pump inhibitors with the main ingredient pantoprazole. It is commonly used to treat gastroesophageal reflux disease (GERD), peptic ulcers, NSAID-induced peptic ulcers, or pathological hypersecretory conditions (Zollinger-Ellison syndrome).1. What is Protomac 40?
The main ingredient pantoprazole in Protomac 40 is a benzimidazole derivative of a selective proton pump inhibitor. Pantoprazole inhibits the last stage of acid formation in the stomach by covalently binding to the enzyme system (H+, K+)-ATPase at the secretory surface of gastric parietal cells. This mechanism inhibits both conventional and stimulant gastric acid secretion mechanisms. Binding to the enzyme system (H+, K+)- ATPase will produce an anti-acid effect lasting more than 24 hours for all doses tested
Scar healing rate (ulcer healing) can be up to 95% after 8 weeks of treatment. Protomac has little effect on gastric volume, pepsin secretion, gastric endogenous factor, and gastric contractility. Protomac 40 is usually indicated in the following cases:
Gastroesophageal reflux disease (GERD) Gastrointestinal ulcers Prevention of peptic ulcers caused by non-steroidal anti-inflammatory drugs Pathological hypersecretion (Zollinger-Ellison syndrome) However, Protomac is contraindicated in patients with known hypersensitivity to pantoprazol or any of the ingredients or other benzimidazole derivatives (e.g. esomeprazole, lansoprazole, omeprazole, rabeprazole).
2. Dosage of Protomac 40
Protomac is usually taken by mouth, taken once a day in the morning, swallowed whole, not crushed or chewed. Depending on the subjects and treatment goals, the dosage of Protomac will be different, specifically as follows:
Treatment of gastroesophageal reflux:
Usual dose: 20-40 mg x 1 time/day for 4 weeks, can be extended up to 8 weeks Maintenance dose: 20-40 mg/day In case of recurrence: 20 mg/day Treatment of peptic ulcer:
Usual dose: 40 mg x 1 time/day. Treatment duration from 2-4 weeks for duodenal ulcer or 4-8 weeks for benign gastric ulcer H. pylori eradication: a 1-week triple combination therapy regimen: Pantoprazol 40 mg x 2 times/ daily in combination with clarithromycin 500 mg x 2 times/day and amoxicillin 1 g x 2 times/day or metronidazole 400 mg x 2 times/day Prevention of ulcers caused by non-steroidal anti-inflammatory drugs (NSAIDs): 20 mg/day
Treatment of syndromes Zollinger-Ellison syndrome: Initial dose: 80 mg/day, up to 240 mg/day may be used. If using 80 mg/day should be divided into 2 times
Treatment of special patients:
Patients with liver failure: the maximum dose can be used is 20 mg/day or 40 mg/day for alternate days. Patients with renal impairment: maximum dose of 40 mg/day
3. Side effects of Protomac
In some patients when using Protomac, side effects may occur such as:
Headache, fatigue Skin rash, urticaria, itching Muscle pain, joint pain Weakness, dizziness, dizziness Increased liver enzymes perspiration, peripheral edema, malaise, anaphylaxis, maculopapular rash, acne, alopecia, exfoliative dermatitis, angioedema, erythema stomatitis, belching, gastrointestinal disturbances Blurred vision, agoraphobia light Insomnia, somnolence, agitation or inhibition, tinnitus, tremor, confusion, hallucinations, paresthesias Hematuria, interstitial nephritis Hepatitis, jaundice, encephalopathy in liver failure, elevated triglycerides Decrease in sodium blood
4. Be careful when using Protomac
Some general precautions when using Protomac:
Long-term use of proton pump inhibitors such as Protomac may increase the risk of hip, wrist and spine fractures, which mainly occur in the elderly. or when other risk factors are present. Therefore, patients at risk of osteoporosis must receive adequate care and supplement with vitamin D and calcium. The patient's response to treatment with pantoprazol did not prevent the progression of gastric tumors. The possibility of malignant peptic ulceration should be excluded prior to administration because pantoprazole may mask symptoms thereby delaying the diagnosis. Patients receiving Protomac may experience mild and transient elevations in liver enzymes. Safety and effectiveness in children under 18 years of age have not been established There are no adequate and well-controlled studies of pantoprazole in pregnant women. Women who are pregnant should not take pantoprazole except when clearly needed. The drug is distributed in breast milk; discontinue nursing or discontinue use due to potential risks to the nursing infant. The drug may cause adverse effects. side effects such as dizziness and visual disturbances so do not drive or operate machinery
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