What is Panfor sr 1000?

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Panfor sr 1000 is indicated for the support and treatment of patients with non-insulin dependent type 2 diabetes. Before and during the use of the drug, the patient should strictly follow the dosage recommendations that the doctor has instructed to achieve the optimal effect.

1. What is Panfor sr 1000?

Panfor sr 1000 is a medicine used to help support or treat type 2 diabetes in adults, used alone or in combination with insulin or other oral diabetes medications. In addition, Panfor sr 1000 is also used to support exercise and diet regimens to control blood sugar in diabetics.
Panfor sr 1000 is a slow release tablet, manufactured by Inventia Healthcare Ltd. The drug has an oval shape, white - ivory white with 2 sides and one side engraved with lines. Panfor sr-1000 is packaged in 5 blisters x 10 tablets. Each tablet of Panfor sr-1000 contains the following ingredients:
Main ingredients: Active ingredient metformin hydrochloride corresponding to 1000mg Other excipients just enough for one tablet: Carboxymethylcellulose sodium (KDA 8 M 30), hypromellose (K) 100M), macrogol (PEG 6000), methacrylic acid copolymer dispersion Drug L 30 D, magnesium stearate and povidone K 90.

2. Indications and uses of Panfor sr 1000

2.1. Indications to use Panfor sr 1000

Panfor sr-1000 is usually prescribed by doctors for the following cases:
Support treatment for people with type 2 diabetes who are not insulin dependent when they have changed their lifestyle or implemented a regimen. diet and exercise actively but still not well control blood sugar index. Used alone or in combination with other diabetes medications to help effectively control blood sugar levels.

2.2. Uses of Panfor sr 1000

Pharmacodynamics
The active ingredient metformin hydrochloride has antihyperglycaemic effects, improving glucose tolerance in people with non-insulin dependent type 2 diabetes. In addition, this active ingredient also has the ability to reduce blood glucose levels both after eating and basal levels. Different from the sulfonylurea group, metformin hydrochloride has a specific mechanism of action as follows:
Inhibition of gluconeogenesis combined with glycogenolysis to help reduce glucose production in the liver. Increases insulin sensitivity thereby increasing peripheral glucose uptake in the muscle. Slows down the absorption of glucose in the intestines. In addition, metformin hydrochloride did not cause hypoglycaemia in both diabetic and healthy subjects, and did not have a hyperinsulinemic effect. During treatment with metformin hydrochloride, insulin secretion remains normal, but plasma insulin levels during the day and fasting insulin may be reduced, respectively.
Pharmacokinetics
Absorption After oral administration, peak blood concentrations of Panfor sr-1000 are usually 7 hours, with an average of 4-8 hours. For repeated doses of the delayed-release form, the active ingredient metformin hydrochloride does not accumulate in plasma. When taken with food, the absorption time of metformin hydrochloride tends to increase by nearly 50%, but does not affect Tmax and Cmax.
Distribution Metformin hydrochloride is hardly bound to plasma proteins. The steady-state plasma concentration of metformin at the usual therapeutic dose is after 24 - 48 hours, reaching values ​​< 1 μg/ml. Metabolism and Elimination Metformin hydrochloride is not metabolised by the liver, and is excreted unchanged in the urine (not via bile). Overall, renal clearance is approximately 3.5 times higher than creatinine clearance, indicating that the main route of elimination for metformin is tubular secretion. Approximately 90% of the drug after oral administration will be absorbed and excreted by the kidneys within the first 24 hours, the plasma half-life is usually about 17.6 hours.

3. Dosage and how to use Panfor sr 1000

3.1. Dosage of Panfor sr 1000

Depending on the effect and tolerability of the drug for each patient, the doctor can determine the appropriate dose. Patients with type 2 diabetes should not take more than 2000mg of metformin/day.
Adult dose
The usual starting dose of Panfor sr-1000 is 500mg once a day, taken with the evening meal. Increase dose in increments of 500mg/week and maximum dose is 2000mg/time/day. If a dose of 2000mg/time/day does not provide effective blood sugar control, patients can try taking a dose of 1000mg x 2 times/day. In case you are taking another diabetes medication and want to switch to Panfor sr-1000, you need to stop taking that drug and only use Panfor at the dosage recommended above. Dose for patients in combination with insulin
The starting dose of metformin hydrochloride is 500mg/time/day after adjusting the insulin dose accordingly based on the patient's blood glucose readings.
Dosage for elderly patients
Adjust the dose of metformin hydrochloride for the elderly based on renal function, because these patients are often at high risk for renal impairment. In addition, elderly people with type 2 diabetes should also have their kidney function evaluated regularly to determine the right dose of medication. Avoid using up to the maximum dose of metformin.
Children's dose
Children under 17 years old should not use Panfor sr-1000.

3.2. How to use Panfor sr 1000

People with type 2 diabetes should take Panfor sr-1000 with water/white water with meals. When taking, pay attention to swallow the tablet whole, avoid chewing, crushing or breaking the medicine. In addition, patients should not take the drug with beer, alcohol and other stimulants because these drinks can reduce the effect of metformin. In addition to using drugs, patients also need to maintain a regular exercise regimen and eat a scientific diet to improve the effectiveness of treatment.

4. How to deal with overdose or missed dose of Panfor sr 1000

When metformin is taken up to a dose of 85g, patients are at increased risk of developing lactic acidosis. This is an emergency that can lead to death if not treated promptly. Currently, the most effective method to remove metformin and lactate is hemodialysis.
In case of missed dose, users should avoid taking a double dose for the purpose of making up for the missed dose. Instead, patients only need to take their next dose according to the schedule recommended by the doctor.

5. Contraindications to using Panfor sr 1000

Below is a list of subjects who should not use Panfor sr-1000 without a doctor's prescription, including:
Patients with alcoholism. People with liver/kidney failure and complications caused by diabetes. People with symptoms of severe ketoacidosis and lactic acidosis. People with pre-coma and diabetic coma symptoms. The patient has recently undergone surgery after a serious injury or is suffering from an infection. People with coronary artery disease, chronic obstructive pulmonary disease, peripheral vascular disease, heart failure. Women planning to become pregnant, are pregnant/breastfeeding. People with low blood glucose. The patient is injected with an iodine-containing contrast agent. People with gangrene, malnutrition or children under 10 years old. Hypersensitivity to metformin or allergy to other ingredients in the drug.

6. Some side effects when using Panfor sr 1000

Panfor sr-1000 can cause side effects from common to rare, depending on the location of each patient. Specifically:
Most common side effects: Abdominal pain, diarrhea, nausea, vomiting, loss of appetite, metallic taste in the mouth. Rare effects: Lactic acidosis, decreased absorption of vitamin B12, decreased serum concentration, megaloblastic anemia, taste disturbances, gastrointestinal disturbances, hepatitis, abnormal liver function, urticaria , rash, pruritus. When experiencing any of the side effects listed above, the patient should stop using the drug and immediately notify the doctor for timely treatment before leading to dangerous health risks. .

7. What drugs does Panfor sr 1000 interact with?

Below is a list of drugs that can interact with Panfor sr-1000, including:
Cationic drugs (Digoxin, Amilorid, Procainamide, Morphin, Quinine, Ranitidine, ...) that interact with metformin due to their competitive nature through the common tubular system. Furosemide when co-administered with Panfor may increase the maximum concentration of active substance metformin in plasma and blood. Acarbose and some gums lead to a decrease in the body's absorption of metformin hydrochloride. Taking Panfor with alcohol increases the risk of lactic acidosis. Cimetidine when co-administered with metformin resulted in increased peak blood and plasma concentrations. Co-administration of Nifedipine with panfor leads to increased urinary absorption and excretion of metformin. Some drugs that increase blood sugar such as corticosteroids or thiazides can cause loss of blood sugar control if used in combination with Panfor sr-1000.

8. Some notes when using and storing Panfor sr 1000

8.1. Some things to note when using Panfor sr 1000

Before and during the use of Panfor sr-1000, patients should note the following:
Do not use the drug for women who are planning to become pregnant, are pregnant or breast-feeding because the drug may increase the risk of metformin accumulation and effects on the unborn baby as well as the breastfed infant. Use caution when using the drug in patients with high concentration of work such as driving a vehicle or machinery because the drug has a blood glucose lowering effect. The use of Panfor drug is only considered as supportive therapy, so patients with type 2 diabetes need to combine with a reasonable diet to achieve a high treatment effect. Elderly patients at risk of impaired renal function should have their serum creatinine checked before starting the drug. Metformin is mainly excreted by the kidneys, so the risk of accumulation as well as lactic acidosis is increased depending on the degree of renal impairment.

8.2. How to store Panfor sr 1000

Panfor sr-1000 medicine should be stored in a dry, high place, with an ideal temperature below 30 degrees Celsius, avoiding direct exposure to sunlight. In addition, the medicine also needs to be stored in a place with suitable humidity, avoiding the bathroom or locations that are easy to cause mold or create conditions for bacteria to penetrate.

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