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Miconazole is often used in the treatment of a number of diseases such as ringworm, gastrointestinal fungus, eye fungus, vaginal yeast,... So what is Miconazole and how is it used?
1. What is Miconazole? What are the uses of Miconazole?
Miconazole medicine has the main ingredient is miconazole nitrate, is made in the form of gel for throat, topical cream and vaginal suppositories, injection...
Miconazole nitrate has antifungal effect against fungi. common dermatophytes and yeasts, and at the same time it has antibacterial activity against a number of bacilli and gram-positive bacteria. Miconazole inhibits ergosterol biosynthesis in fungi and alters their membrane lipid composition, leading to fungal cell necrosis.
Miconazole belongs to the group of synthetic imidazoles with antifungal effects including candida, aspergillus, blastomyces, cladosporium, coccidioides...
2. Indications and contraindications of the drug Miconazole
Miconazole medicine is indicated in the following cases:
Eye fungus Throat fungus, oral fungus Ringworm Skin fungus Gastrointestinal fungus Vaginal fungus Miconazole drug is contraindicated in the following cases:
People with hypersensitivity to any of the ingredients part of the drug. Hepatic dysfunction Note when using Miconazole in the following cases:
In case it is necessary to use Miconazole with anticoagulants, it is necessary to closely monitor and adjust when necessary. When miconazole is used concomitantly with phenytoin, careful monitoring is also required. Caution should be exercised when administering miconazole to infants and young children, as the gel formulation can cause obstruction. Miconazole gel should not be used on the back of the throat, when it is absolutely necessary to divide it into several small doses, but still need to be monitored to prevent suffocation. Although, there are no studies to show that miconazole is embryotoxic or teratogenic, there is a potential risk. Therefore, miconazole should not be used or should be used with caution in pregnant women. Currently, there are no data to show that Miconazole is excreted in human milk, so you should not use it while breastfeeding. If necessary, use caution or consult a doctor or pharmacist.
3. Dosage and usage of the drug Miconazole
Dosage and use of Miconazole drug should be according to the prescription of a specialist.
If Miconazole overdose is used, there is usually no high toxicity, but sometimes symptoms of vomiting and diarrhea appear. Accordingly, it is necessary to treat symptoms to support, because there is no specific antidote.
4. Side effects of the drug Miconazole
When using Miconazole you may encounter the following side effects:
Miconazole medicine can cause side effects such as digestive disorders, nausea, vomiting. When using gynecological suppositories Miconazole and miconazole cream applied to the skin can produce a burning sensation, skin rash. Miconazole injection can cause nausea, vomiting, and fever. Long-term treatment with Miconazole can cause diarrhea. Rarely, allergic reactions have been observed with the use of Miconazole.
5. Miconazole drug interactions
Miconazole inhibits the metabolism of drugs belonging to the cytochrome 3A and 2C9 enzyme systems. From there, it prolongs the effects of these drugs, including the side effects. Drugs such as terfenadine, astemizole and cisapride,... are inhibited by miconazole, so they should not be used concurrently or in combination.
Oral anticoagulants, hypoglycaemic agents, cyclosporin, phenytoin and tacrolimus should also be reduced in dose when necessary concurrent use with miconazole.
Miconazole drug is often used in the treatment of a number of diseases such as ringworm, gastrointestinal fungus, eye fungus, vaginal yeast,... To ensure effective treatment and avoid side effects, patients need to take medicine according to prescription or consult a doctor or pharmacist.
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