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Mibecerex is used in the treatment of osteoarthritis, rheumatoid arthritis, and some painful conditions. So what is Mibecerex and how is it used?
1. What is Mibecerex?
Mibecerex medicine has the main ingredient Celecoxib 200mg. Celecoxib is a non-steroidal anti-inflammatory drug (NSAID), which selectively inhibits cyclooxygenase-2 (COX-2), thereby inhibiting the synthesis of prostaglandins, so the drug has anti-inflammatory, analgesic, antipyretic effects. .
Unlike most previous non-steroidal anti-inflammatory drugs, Celecoxib does not inhibit the cyclooxygenase-1 (COX-1) isoenzyme, so it has a lower risk of side effects.
2. Indications and contraindications of the drug Mibecerex 200mg
Mibecerex 200mg drug is indicated in the following cases:
Symptomatic treatment of osteoarthritis in adults. Symptomatic treatment of rheumatoid arthritis in adults. Support in the treatment of familial adenomatous colorectal polyposis. Treatment of acute pain, after surgery, tooth extraction. Treatment of primary dysmenorrhea. Mibecerex 200mg drug is contraindicated in the following cases:
People who are sensitive to the ingredients of the drug, sulfonamides. People with heart failure, kidney failure, severe liver failure. People with inflammatory bowel disease. People with a history of allergic reactions to aspirin or other NSAIDs. Caution should be taken when using Mibecerex 200mg in the following cases:
Care should be taken when using Mibecerex for people with a history of peptic ulcer, gastrointestinal bleeding, the elderly, debilitated people, because risk of gastrointestinal toxicity. Use caution when using Mibecerex 200mg for people with edema, fluid retention because the drug causes fluid retention. Mibecerex 200mg should be used with caution in people with extracellular water loss (due to strong diuretics). Dehydration must be treated before taking Mibecerex.
3. Dosage and how to use Mibecerex 200mg
Mibecerex 200mg is taken orally. Dosage of Mibecerex 200mg drug in each specific case is as follows:
Treatment of osteoarthritis: Use a dose of 200mg/day, orally once or divided into 2 equal doses. The dose can be adjusted according to the needs and response of the patient. Symptomatic treatment of rheumatoid arthritis: Use a dose of 100-200mg/time x 2 times/day. Adjuvant treatment in colorectal polyps: Use dose 400mg/time x 2 times/day. Relieve dysmenorrhea: In the first day, the dose is 400mg/time, followed by 200mg if needed. In the following days, a dose of 200mg x 2 times/day can be used if needed. Note: The above dosage of Mibecerex 200mg is for reference only. The specific dose will depend on the condition and the progression of the disease. Therefore, you should consult a specialist.
When using Mibecerex drug overdose you may have the following symptoms: Drowsiness, lethargy, nausea, vomiting, epigastric pain, gastrointestinal bleeding. Even anaphylactoid reactions may occur.
Treatment of overdose with Mibecerex 200mg includes symptomatic and supportive treatment. During the first 4 hours after an overdose of Mibecerex, the doctor may prescribe vomiting and/or oral activated charcoal, and/or oral osmotic bleach.
If you forget a dose of Mibecerex, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and take your next dose at the scheduled time, do not take a double dose.
4. Side effects of Mibecerex 200mg
Common of the drug Mibecerex 200mg include:
Digestion: Abdominal pain, indigestion, flatulence, nausea, diarrhea. Respiratory: Pharyngitis, rhinitis, sinusitis. Nervous system: Insomnia, dizziness, headache. Musculoskeletal system: Back pain. Immunity: Peripheral edema. Rare side effects of Mibecerex 200mg include:
Cardiovascular: Syncope, ventricular fibrillation, congestive heart failure. Respiratory: Pulmonary embolism. Gastrointestinal: Intestinal obstruction, gastrointestinal bleeding, intestinal perforation. Hepatobiliary: Gallstones, hepatitis, jaundice. Pancreatitis Blood: Thrombocytopenia, agranulocytosis. Metabolism: Decreased blood glucose. When experiencing side effects of Mibecerex 200mg, you need to stop using the drug and notify your doctor for timely treatment.
5. Interactions of Mibecerex 200mg with other drugs
Caution is advised when using Mibecerex with drugs that inhibit the enzyme P450 209. In addition, Celecoxib also inhibits cytochrome P450 2D6 so it has the potential to interact with drugs metabolized by this enzyme. Angiotensin-converting enzyme inhibitors: Mibecerex 200mg reduces the antihypertensive effect of these drugs. Diuretics: Mibecerex may reduce the Na+ elimination effect of furosemide and thiazides. Aspirin: Taking these two drugs together may increase the risk of peptic ulcers. Lithium: Mibecerex may decrease renal clearance of lithium, leading to increased lithium toxicity. Warfarin: Bleeding complications associated with increased prothrombin time may occur when Mibecerex is co-administered with Warfarin. Mibecerex is used to treat osteoarthritis, rheumatoid arthritis, and to treat certain painful conditions. To ensure the effectiveness of treatment and avoid unwanted side effects, patients need to take medicine according to prescription or consult a doctor, professional pharmacist.
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