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Metazydyna belongs to the group of cardiovascular drugs whose main ingredient is trimetazidine. The drug has the effect of increasing ATP energy - the energy supplied to heart muscle cells, preventing the manifestations of ischemic heart disease. How is Metazydyna currently used?
1. What is Metazydyna?
Metazydyna drug has the main ingredient trimetazidine, which helps to stabilize cellular energy in the state of systemic hypoxia or ischemia. Metazydyna helps to suppress the electrophysiological manifestations of ischemia, reduces the ST segment elevation in the electrocardiogram of the site of myocardial infarction. Thanks to the presence of trimetazidine, the intracellular acidosis caused by ischemia is greatly reduced and rapidly returns to near normal. In addition, trimetazidine has the following effects:
Prevents a decrease in the energy supply of ATP in cardiac muscle cells Prevents a decrease in ATP and cyclic AMP stores in brain cells Maintains functional activity of enzymes mitochondria, the site of cellular energy production in hepatocytes Reduce the toxicity of oxidized free radicals in cellular ischemia, thereby providing a protective effect on the cell against reduction tissue oxygenation Prevents free radicals and lipid oxidation thereby reducing arteriosclerosis and stabilizing cell membranes Shortening the duration of ventricular fibrillation Metazydyna is usually indicated in the following cases:
Prevention and treatment of angina pectoris vascular damage to the retina Vasomotor vertigo, Meniere's syndrome, tinnitus Metazydyna drug has the following contraindications:
Patients with hypersensitivity to any component of the drug Metazydyna Disease Patients with heart failure, heart failure Patients with movement disorders, tremor, Parkinson's disease Patients with severe renal failure
2. Dosage of the drug Metazydyna:
Metazydyna is usually taken orally with a meal, do not break or crush the tablet because it may affect bioavailability. Depending on the purpose of treatment, the dose of Metazydyna will be different:
In the treatment of lesions in the ears and eyes: use a dose of 40-60 mg tablets, divided into 2-3 oral doses. Coronary heart failure, angina pectoris: 20 mg/day x 3 times, then can reduce to 20 mg x 2 times/day For patients with moderate renal impairment: reduce dose compared to usual, take 2 times, dose 20mg equivalent to 1 tablet /times morning and evening Dosage for the elderly will be the same as that of patients with renal failure There has been no study on the effect of the drug on the age of less than 18 years, so Metazydyna should not be used in this subject.
3. Side effects of the drug Metazydyna:
In some patients when using Metazydyna, side effects may occur such as:
Gastrointestinal symptoms: nausea, loss of appetite, epigastric discomfort, stomach Elevated liver enzymes Headache
4. Be careful when using the drug Metazydyna
Some general notes when using Metazydyna include:
There are not enough studies on the activity of the drug in pregnant women, it is not known whether it causes fetal malformations or not, so avoid using Metazydyna on pregnant women. this statue. There are currently no reports of the excretion of trimetazidine in breast milk and therefore should not be used in lactating women. Metazydyna drug can cause side effects such as headache, dizziness, impaired concentration and alertness while driving or operating machinery. Use caution. There are currently no reports of drug interactions. Metazydyna, however, still needs to consult a doctor before using in combination with other drugs to ensure safety and effective treatment.
Hopefully with the sharing of Metazydyna drug, it will help the process of using the drug and treating patients with high efficiency, minimizing the impact on health.
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