Uses of the drug ramizes 5

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1. What is Ramizes 5?

Ramizes 5 belongs to the group of cardiovascular drugs with the main ingredient being the active ingredient Ramipril 5mg and excipients just enough for 1 tablet. The drug is manufactured by Farmak JSC - U CRAI NA and is prepared in the form of tablets in a box of 3 blisters x 10 tablets.

2. Effects and indications for using Ramizes 5

2.1. Effects of Amlodipine Ramipril is an active ingredient in the group of Angiotensin-converting enzyme inhibitors that have the following effects:
Peripheral vasodilation Reduces vascular resistance Lowers blood pressure Decreases left ventricular hypertrophy and fibrosis Reduces preload/afterload Increases filtration glomeruli Decreased excretion of Aldosterone Potassium-sparing diuretic Increase sodium excretion Increase insulin sensitivity, good for diabetics. Improved cardiac output Ramipril is rapidly and well absorbed orally, with a bioavailability of 54-64%. The active ingredient Ramipril achieves high plasma concentrations about 1-3 hours after dosing.
Ramipril is eliminated and metabolised largely in the liver and kidneys in the form of active metabolites that have been metabolised. In addition, Ramizes 5 is rapidly and well absorbed orally, with a bioavailability of 54 - 64%. In particular, the active ingredient Ramipril reaches peak plasma concentrations 1-3 hours after taking the drug.
2.2. Indications of the drug Ramizes 5 Drug Ramizes 5 is used for the following cases:
Hypertension. Hypertension with heart failure. Patients are at high risk of coronary heart disease, diabetes, kidney disease and cerebrovascular accident. Congestive heart failure after infarction. Congestive heart failure after left ventricular failure. In combination with thiazide diuretics in the treatment of hypertension. In combination with Digitalis in the treatment of congestive heart failure. In combination with cardiac glycosides, beta blockers. Prevention of cardiovascular events in patients over 55 years of age at high risk of cardiovascular disease.

3. How to use Ramizes 5 properly

3.1. Dosage Ramizes 5 is a prescription medication. Therefore, the use of the drug should be prescribed by a doctor or pharmacist. Patients are not allowed to arbitrarily use the drug as well as change the dose without permission.
In addition, the dose of Ramipril is highly dependent on the severity of the disease as well as the individual response to the drug. Patients can refer to the commonly used dosage as follows:
Treatment of hypertension:
The first dose is 1.25mg Ramipril/time/day. Evaluate the effectiveness after 2 weeks of taking Ramipril, if the patient does not respond well, the dose should be gradually increased. The maintenance dose of Ramipril is usually 2.5-5mg/time and not more than 2 tablets/time/day. If the use of Ramizes 5 does not respond to monotherapy, a combination with a diuretic may be considered. Treatment of congestive heart failure:
Initial dose: 1.25mg Ramipril/time/day. If the drug does not improve after 1 to 2 weeks, the dose can be increased to 2 tablets / day. Maintenance dose 2.5mg/time and 1-2 times/day. Treatment of congestive heart failure after myocardial infarction 3 - 10 days:
Initial dose: 2.5mg Ramipril/time and 2 times/day. Increase the dose to 1 tablet / time after 2 days of taking the drug and taking it twice a day. In cases where the patient does not tolerate Ramipril well, the dose should be started from 1.25 mg twice a day for 2 days. Then increase the dose to 2.5 mg/time, 2 times/day. Maintenance dose should be stopped at 5mg/time, 2 times/day. Prevention of cardiovascular events:
The first dose is 2.5mg Ramipril/time, 2 times/day. Increase dose to 5mg/time/day after 7 days of dosing. Then increase to 10mg/time/day. Impaired liver and kidney function:
Patients with creatinine clearance < 30ml/min: the initial dose should not exceed 1.25mg/day and the maintenance dose should not exceed 5mg/day. In patients with creatinine clearance < 10 ml/min (severe renal impairment), the maintenance dose of Ramipril should not exceed 2.5 mg/day. To achieve the most effective treatment, patients need to strictly follow the instructions of the treating doctor and pharmacist.
3.2. How to use Ramizes 5 is made in the form of capsules, so it should be taken orally. Patients should take the drug about 1 hour before meals.
In addition, the drug can cause a side effect of low blood pressure, so it should be taken at night before going to bed.
3.3. What to do in case of missed dose or overdose? Missed dose: If you miss a dose, skip the missed dose and take your medicine as usual. Do not double the prescribed dose for the purpose of making up for the dose. In case of overdose: if experiencing an overdose or emergency, the patient should immediately go to the nearest medical facility. In this case, it will be managed with intravenous fluids to increase blood pressure when hypotension, rehydration and electrolyte balance.

4. Contraindications to using Ramizes 5

Do not use Ramizes 5 in the following cases:
Patients with a history of allergy to Ramipril, ACE inhibitors or other ingredients in the drug. The patient has a history of angioedema caused by an allergy to ACE inhibitors. Patients with a history of or with hypotension. Aortic valve stenosis. Obstructive cardiomyopathy. Patients with renal artery stenosis. Women who are pregnant or breastfeeding. People with kidney failure. Do not use Ramizes 5 for people < 18 years old.

5. Side effects when using Ramizes 5

During the use of Ramipril, patients may experience some unwanted side effects as follows:
Headache, dizziness Dry cough Digestive disturbances, diarrhea Nausea Low blood pressure Itching, rash Edema Vascular neutropenia Hepatocyte damage Asthenia, fatigue Chest pain, arrhythmia Fever Depression Renal failure Joint pain Jaundice, cholestasis, liver failure Hyperkalemia Agranulocytosis If the patient presents If any of the above symptoms occur and become severe, immediately notify your doctor or health care professional who has the best advice and appropriate treatment.

6. Drug Interactions Ramizes 5

Some drug interactions may occur when combining Ramizes 5 with the following drugs:
Potassium-sparing diuretics because it can cause a drop in blood pressure. Lithium Diabetic Drugs Non-steroidal anti-inflammatory drugs will decrease renal function and increase serum potassium levels. Glucocorticoid antidepressants To ensure safety and avoid drug interactions, patients should inform their doctor, pharmacist of all the drugs they are using or when unusual signs appear during use. drug Ramizes 5 .

7. Note when using the drug Ramizes 5

Patients should carefully read the medication instructions listed on the package insert when using Ramizes 5. In addition, patients can consult a doctor or refer to some of the following notes:
Caution when using Ramipril in combination with drugs to treat kidney disease, bilateral renal artery stenosis, or people who are suffering from kidney disease. surgery, anesthesia. Because Ramipril can cause side effects such as dizziness and headache. Therefore, it should be used with caution when driving, operating machinery or working at height. Do not use Ramizes 5 for pregnant women and nursing mothers. Store the drug at a temperature below 30 degrees Celsius, do not expose the medicine to sunlight. The above article is detailed information about the Ramizes 5 drug line. Patients should not arbitrarily buy drugs to use at home without the appointment of medical professionals, to limit the side effects affecting health.
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