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Lostad T50 is a prescription drug in the treatment of a number of cardiovascular diseases. So what is Lostad T50 and how is it used?
1. What disease does Lostad T50 treat?
Lostad T50 is a drug to treat high blood pressure, which is made in the form of film-coated tablets, the main ingredient in each tablet is Losartan potassium 50mg.Losartan and its metabolite block Angiotensin II from causing vasoconstriction and aldosterone secretion by selectively inhibiting the binding between Angiotensin II and the AT1 receptor found in many body tissues. It dilates blood vessels and lowers blood pressure.
Lostad t50 is indicated in the following cases:
Heart failure Myocardial infarction. Increases blood pressure, especially in patients with cough, with angiotensin-converting enzyme inhibitors and helps reduce the risk of stroke in patients with left ventricular hypertrophy. Kidney disease in patients with diabetes (serum creatinine about 1.3 - 3.0 mg/dl, weight ≤ 60 kg and 1.5 - 3.0 mg/dl in men over 60 kg and proteinuria). Lostad t50 is contraindicated in cases of hypersensitivity to any of its components.
2. How to use and dosage of Lostad T50
Lostad t50 is used by mouth, taking whole tablets, do not chew, crush or break tablets. The dose of Lostad t50 should be according to the doctor's prescription. The recommended dose for specific cases is as follows:
Treatment of hypertension in adults: The usual dose is 1 tablet/time/day. If necessary, the dose can be increased to 2 tablets / time / day or taken 1 tablet / time, 2 times a day. Lostad t50 achieves the maximum antihypertensive effect 3 to 6 weeks after starting treatment. Patients with reduced intravascular volume, patients with liver and kidney failure: The starting dose is 25mg/time/day. Treatment of kidney disease in patients with type 2 diabetes: The starting dose is 1 tablet once a day, the dose can be increased to 2 tablets once a day depending on the response on blood pressure. If you forget a dose of Lostad t50, take the replacement dose as soon as you remember. However, if it is almost time for your next dose, skip the missed dose. Do not take a double dose of Lostad t50 to make up for a missed dose.
The most common symptom of overdose Lostad t50 is hypotension and tachycardia, bradycardia may also occur. Supportive treatment is required according to the patient's symptoms.
3. Side effects of the drug Lostad T50
Lostad t50 side effects are usually mild and transient such as:
Dizziness Headache Orthostatic hypotension Rare side effects of Lostad t50 include:
Renal dysfunction Itching, rash, urticaria Angioedema Elevated liver enzymes Rhabdomyolysis syndrome A side effect of hypotension may occur, especially in patients with intravascular volume depletion (patients taking high-dose diuretics). Side effects of Lostad t50 such as hyperkalemia, muscle pain, arthralgia have been reported.
Other side effects of Lostad t50 include:
Back pain Fatigue Respiratory disorders Digestive disorders Neutropenia. If you experience any side effects of Lostad t50, you need to immediately notify your doctor or go to the nearest medical facility for timely treatment.
4. Lostad t50 drug interactions with other drugs
Fluconazole increases the concentration of losartan when co-administered. Indomethacin reduces the antihypertensive effect of Lostad t50. Hyperkalemia occurs when Lostad t50 is used concomitantly with potassium supplements, potassium-sparing diuretics, or salt substitutes containing potassium. Rifampicin reduces concentrations of losartan and its active metabolite when co-administered. Knowing the information about the drug Lostad t50 will help the process of using the drug better and limit the side effects from the drug.
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