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Lostad T25 contains the main active ingredient, losartan, is indicated for the treatment of hypertension, especially in patients with cough when taking angiotensin converting enzyme inhibitors, to reduce the risk of stroke in patients with left ventricular hypertrophy. . To ensure the effectiveness of treatment and avoid side effects, patients need to take the drug according to the instructions of the doctor, professional pharmacist.1. What is Lostad t25?
What is the drug Lostad t25? Lostad T25 contains the active ingredient losartan, which blocks the vasoconstrictor and aldosterone-secreting effects of angiotensin II by selectively inhibiting the binding of angiotensin II to the AT1 receptor found in many tissues (eg. : Vascular smooth muscle, adrenal gland).
Lostad T25 is manufactured by Stellapharm Co., Ltd. Lostad T25 is produced in the form of film-coated tablets. The outside of the tablet has a round shape, a white film-coated surface, and the two meniscus faces are engraved.
2. Uses of the drug Lostad T25
2.1. Indications Lostad T25 is indicated by doctors for use in the following cases:
Lostad T25 is indicated for the treatment of hypertension, especially in patients with cough when taking angiotensin converting enzyme inhibitors, reducing the risk of stroke in patients with left ventricular hypertrophy. Lostad T25 is indicated for the treatment of kidney disease in patients with diabetes mellitus (serum creatinine in the range 1.3 - 3.0 mg/dl in patients < 60 kg and 1.5 - 3.0 mg/dl in patients < 60 kg and 1.5 - 3.0 mg/dl in patients < 60 kg and 1.5 - 3.0 mg/dl. dl in men > 60 kg and proteinuria In addition, Lostad T25 is also indicated for the treatment of heart failure and myocardial infarction
2.2 Dosage of Lostad T25 Lostad T25 is taken orally. Patients need to strictly follow the instructions on dosage and use of the doctor or pharmacist. If necessary, the doctor may increase the dose to 100 mg X 1 time / day or divided into 2 times / day The maximum antihypertensive effect can be achieved after starting treatment about 3 - 6 A starting dose of 25 mg once daily is used in patients with low intravascular volume. This dose is also suitable for patients with hepatic and renal impairment. Kidney disease in patients with type diabetes 2
Initial dose is 50 mg x 1 time/day However, your doctor may prescribe an increase in dose to 100 mg once daily. However, it will depend on the patient's blood pressure response.
Children
From 6 years of age and older, if you have hypertension, you can use the starting dose of 0.7 mg/kg x 1 time/day. However, the maximum dosage is 50 mg. The doctor may adjust the dose according to the response; Dosages higher than 1.4 mg/kg or 100 mg/day have not been specifically studied.
Note: The dose of Lostad T25 above is for reference only. Therefore, the specific dose will depend on the condition, as well as the progression of the disease. To have the most appropriate dose of Lostad T25, patients need to consult their doctor, pharmacist or medical staff.
3. Management of overdose and missed dose Lostad T25
Currently, the data on the overdose of Lostad T25 is very limited. Accordingly, the most common manifestations of overdose were recorded as tachycardia, bradycardia, hypotension, and parasympathetic (vagal) stimulation. Therefore, if symptoms of severe hypotension occur, supportive measures should be instituted. Do not remove losartan or its active metabolite by hemodialysis.
If you forget to take a dose of Lostad T25, take it as soon as you remember. If the time interval for the next dose is too close, skip the missed dose and take a new dose as usual. Never use a double dose to make up for it.
4. Notes when using Lostad T25
Before using Lostad T25, patients should carefully read the instructions for use and pay attention to the following issues:
Lostad T25 is contraindicated in patients with hypersensitivity to losartan potassium or any of its ingredients. any of the drugs. During the use of Lostad T25, patients may experience some side effects such as orthostatic hypotension, dizziness, dizziness, insomnia, diarrhea, hyperkalemia, back pain, muscle pain, etc. .. These lists may not be complete when using Lostad T25. Therefore, during use, if any abnormal signs are detected, the patient should immediately notify the doctor for examination and treatment. Use caution when using losartan in patients with renal artery stenosis. Active ingredient Losartan is excreted in the urine and in the bile. Therefore, the dose should be reduced in patients with renal impairment and should be considered when used in patients with hepatic impairment. Patients with intravascular volume depletion may experience hypotension. Therefore, intravascular volume reduction should be adjusted prior to administration of Lostad T25 or a lower starting dose than recommended. Because the use of Lostad T25 can increase blood potassium, it is necessary to monitor the serum potassium concentration, especially in the elderly, in patients with renal impairment, and avoid using it with potassium-sparing diuretics. . Lostad T25 is a medicine that contains lactose. Therefore, Lostad T25 should not be used in patients with a history of rare hereditary diseases such as galactose intolerance, glucose - galactose malabsorption, total lactase deficiency. The ability to drive and use machines: There are no studies on the effects or adverse effects on the ability to use machines and to drive with the use of Lostad T25. However, when having to do tasks that require high concentration, patients still need to pay attention, because drowsiness and dizziness may occur when taking antihypertensive drugs, especially when starting treatment. treatment or when increasing the dose of the drug. Pregnancy: If Lostad T25 is used during the 2nd and 3rd trimesters of pregnancy, the drug can directly affect the renin - angiotensin system causing damage, even death to the fetus. . Therefore, stop taking losartan as soon as possible if you find out you are pregnant. Lactation: Because Lostad T25 has an effect on nursing infants, mothers should consider stopping breast-feeding or discontinuing use of the drug. The doctor will weigh the benefits and risks of the drug with the mother. Therefore, patients should strictly follow the instructions of the doctor and pharmacist.
5. Lostad T25 drug interactions
Currently, in drug interaction studies, there are not many significant pharmacokinetic interactions between the active ingredient losartan and hydrochlorothiazide, digoxin, warfarin, cimetidine and phenobarbital. Rifampin is an inducer of drug metabolism, and concomitant administration of losartan and its active metabolite may decrease concentrations. Because fluconazole is a P450 2C9 inhibitor, concomitant use will reduce the concentration of the active metabolite and increase the concentration of losartan. Angiotensin II receptor blockers or ACE inhibitors when used concomitantly with potassium-sparing diuretics (eg, spironolactone, triamterene, amiloride), potassium supplements, or concomitant use with salt substitutes containing salts Potassium can lead to hyperkalemia. As with other antihypertensive drugs, the antihypertensive effect of losartan will be reduced if indomethacin, a non-steroidal anti-inflammatory drug, is used. Because there are currently no studies on the incompatibility of the drug Lostad T25. Therefore, this medicine should not be mixed with other drugs. Store Lostad T25 in a tightly closed container, in a dry place and away from direct light. Lostad T25 contains the active ingredient losartan, which is indicated for the treatment of hypertension, especially in patients with cough when taking an angiotensin-converting enzyme inhibitor, to reduce the risk of stroke in patients with left ventricular hypertrophy. To ensure the effectiveness of treatment and avoid side effects, patients need to take the medicine exactly as directed by the doctor, professional pharmacist.
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